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Table 2 Demographic and clinical characteristics of NMOSD with and without CTD

From: Neuromyelitis optica spectrum disorders with and without connective tissue disorders

  NMOSD (39) NMOSD with CTD (18) P
Gender, n (% female) 37 (94.9%) 18 (100%) 0.839
Age at onset, years 39.97 ± 13.82 42.33 ± 11.29 0.530
Follow-up duration, years 5.63 ± 4.63 5.04 ± 3.83 0.641
Annualized relapse rate (ARR) 0.98 ± 0.54 1.40 ± 1.51 0.127
ARR before regular medication 1.58 ± 2.18 1.66 ± 1.44 0.899
ARR after regular medication 0.64 ± 0.79 1.39 ± 1.96 0.100
Number of attacks 3.97 ± 2.07 4.28 ± 2.32 0.623
Neuropathic pain, n (%) 21 (53.8%) 10 (55.6%) 0.904
EDSS at nadir 3.5 (1, 8) 4 (1.5, 8.5) 0.031*
 Visual functions 0 (0, 6) 1 (0, 6) 0.139
 Pyramidal functions 1 (0, 4) 2 (0, 4) 0.219
 Sensory functions 2 (0, 4) 3 (0, 4) 0.007*
 Bowel and bladder 0 (0, 5) 3 (0, 5) 0.256
EDSS at last follow-up 2 (1, 8) 2.5 (1.5, 8.5) 0.403
 Visual functions 0 (0, 4) 1 (0, 6) 0.111
 Pyramidal functions 1 (0, 4) 1 (0, 4) 0.595
 Sensory functions 1 (0, 4) 2 (0, 4) 0.063
 Bowel and bladder 0 (0, 5) 0 (0, 5) 0.856
Initial presentation, n (%)
 ON 14 (35.9%) 6 (33.3%) 0.850
 Area postrema syndrome 8 (20.5%) 2 (11.1%) 0.622
 AM 15 (38.5%) 9 (50.0%) 0.412
 Others 2 (5.1%) 1 (5.6%) 1.000
  1. Abbreviations: NMOSD neuromyelitis optica spectrum disorders, CTD connective tissue disorders, EDSS Kurtzke Expanded Disability Status Scale, ON optica neuritis, AM acute myelitis
  2. *P < 0.05