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Table 3 Laboratory features between NMOSD with and without CTD

From: Neuromyelitis optica spectrum disorders with and without connective tissue disorders

  NMOSD (39) NMOSD with CTD (18) P
CSF Index
 Elevated white cell count (> 8 × 106/L), n (%) 5 (12.8%) 5 (27.8%) 0.315
 Elevated protein (> 0.4 g/L), n (%) 12 (30.8%) 5 (27.8%) 0.819
 OCB, n (%) 1 (2.6%) 1 (5.6%) 1.000
 Glu (2.5–4.4 mmol/L) 3.69 ± 1.00 3.19 ± 1.30 0.137
 Cl (119-130 mmol/L) 127.25 ± 5.32 126.29 ± 5.41 0.585
Serums Index
 AQP4-Ab, n (%) 29 (74.4%) 12 (66.7%) 0.548
 IgG (751–1560 mg/dl) 1161.73 ± 393.18 1696.06 ± 760.54 0.013*
 IgA (82-453 mg/dl) 220.90 ± 95.81 372.66 ± 290.69 0.051
 IgM (46–304 mg/dl) 114.47 ± 64.61 89.41 ± 35.85 0.144
 C3 (79–152 mg/dl) 104.64 ± 67.35 99.29 ± 17.12 0.750
 C4 (16–38 mg/dl) 23.20 ± 16.12 22.24 ± 9.92 0.822
 CRP (>  0.8 mg/dl), n (%) 4 (10.3%) 6 (33.3%) 0.079
 IgE (> 165 IU/ml), n (%) 2 (5.1%) 1 (5.6%) 1.000
 ANA (> 1:80), n (%) 22 (56.4%) 17 (94.4%) 0.004*
 Anti-dsDNA, n (%) 1 (2.6%) 1 (5.6%) 1.000
 Anti-nRNP, n (%) 0 (0.0%) 1 (5.6%)
 Anti-Sm, n (%) 0 (0.0%) 1 (5.6%)
 Anti-SSA, n (%) 10 (25.6%) 15 (83.3%) < 0.001**
 Anti-Ro52, n (%) 9 (23.1%) 13 (72.2%) < 0.001**
 Anti-SSB, n (%) 2 (5.1%) 8 (44.4%) 0.001*
 Anti-Scl70, n (%) 0 (0.0%) 0 (0.0%)
 Anti-Jo1, n (%) 0 (0.0%) 0 (0.0%)
 ACA, n (%) 0 (0.0%) 0 (0.0%)
 AnuA, n (%) 0 (0.0%) 3 (16.7%)
 AHA, n (%) 2 (5.1%) 2 (11.1%) 0.792
 ARPA, n (%) 0 (0.0%) 0 (0.0%)
 GPI (> 0.20 mg/L), n (%) 2 (5.1%) 1 (5.6%) 1.000
 RF (> 20 IU/ml), n (%) 3 (7.7%) 7 (38.9%) 0.012*
 ASO (> 116 IU/ml), n (%) 4 (10.3%) 3 (16.7%) 0.802
 globulin (53.8–68.2) 66.91 ± 3.43 63.07 ± 6.61 0.032*
 α1 globulin (1.1–3.7%) 2.17 ± 0.52 2.46 ± 1.45 0.328
 α2 globulin (8.5–14.5%) 9.05 ± 1.35 8.97 ± 1.40 0.843
 βglobulin (8.6–14.8%) 8.92 ± 1.51 8.97 ± 2.22 0.926
 γglobulin (9.2–18.2%) 12.95 ± 3.13 16.87 ± 6.35 0.023*
  1. Abbreviations: NMOSD neuromyelitis optica spectrum disorders, CTD connective tissue disorders, CSF cereberal spinal fluid, OCB oligoclonal bands, Glu glucose, Cl chloride, C complements, CRP C-reactive protein, ANA antinuclear antibodies, Anti-dsDNA anti-double stranded DNA antibodies, Anti-nRNP antinuclear ribonucleoprotein, Anti-Sm anti-Sm antibodies, Anti-SSA/Ro52/SSB Anti-SSA/Ro52/SSB antibodies, Anti-Scl70 anti-topoisomerase I antibodies, Anti-Jo1 anti-Jo-1 antibodies, ACA anti-neutrophil cytoplasmic antibodies, AnuA anti-nucleosome antibody, AHA anti-histone antibody, ARPA anti-ribonucleoprotein antibodies, GPI Glucose-6 phosphate isomerase, RF rheumatoid factor, ASO Anti-streptolysin
  2. **P < 0.001, *P < 0.05