Table 3 Laboratory features between NMOSD with and without CTD

 Elevated white cell count (> 8 × 10⁶/L), n (%)

5 (12.8%)

5 (27.8%)

0.315

 Elevated protein (> 0.4 g/L), n (%)

12 (30.8%)

5 (27.8%)

0.819

 OCB, n (%)

1 (2.6%)

1 (5.6%)

1.000

 Glu (2.5–4.4 mmol/L)

3.69 ± 1.00

3.19 ± 1.30

0.137

 Cl (119-130 mmol/L)

127.25 ± 5.32

126.29 ± 5.41

0.585

 AQP4-Ab, n (%)

29 (74.4%)

12 (66.7%)

0.548

 IgG (751–1560 mg/dl)

1161.73 ± 393.18

1696.06 ± 760.54

0.013*

 IgA (82-453 mg/dl)

220.90 ± 95.81

372.66 ± 290.69

0.051

 IgM (46–304 mg/dl)

114.47 ± 64.61

89.41 ± 35.85

0.144

 C3 (79–152 mg/dl)

104.64 ± 67.35

99.29 ± 17.12

0.750

 C4 (16–38 mg/dl)

23.20 ± 16.12

22.24 ± 9.92

0.822

 CRP (>  0.8 mg/dl), n (%)

4 (10.3%)

6 (33.3%)

0.079

 IgE (> 165 IU/ml), n (%)

2 (5.1%)

1 (5.6%)

1.000

 ANA (> 1:80), n (%)

22 (56.4%)

17 (94.4%)

0.004*

 Anti-dsDNA, n (%)

1 (2.6%)

1 (5.6%)

1.000

 Anti-nRNP, n (%)

0 (0.0%)

1 (5.6%)

–

 Anti-Sm, n (%)

0 (0.0%)

1 (5.6%)

–

 Anti-SSA, n (%)

10 (25.6%)

15 (83.3%)

< 0.001**

 Anti-Ro52, n (%)

9 (23.1%)

13 (72.2%)

< 0.001**

 Anti-SSB, n (%)

8 (44.4%)

0.001*

 Anti-Scl70, n (%)

0 (0.0%)

0 (0.0%)

–

 Anti-Jo1, n (%)

0 (0.0%)

0 (0.0%)

–

 ACA, n (%)

0 (0.0%)

0 (0.0%)

–

 AnuA, n (%)

0 (0.0%)

3 (16.7%)

–

 AHA, n (%)

2 (11.1%)

0.792

 ARPA, n (%)

0 (0.0%)

0 (0.0%)

–

 GPI (> 0.20 mg/L), n (%)

2 (5.1%)

1 (5.6%)

1.000

 RF (> 20 IU/ml), n (%)

3 (7.7%)

7 (38.9%)

0.012*

 ASO (> 116 IU/ml), n (%)

4 (10.3%)

3 (16.7%)

0.802

 globulin (53.8–68.2)

66.91 ± 3.43

63.07 ± 6.61

0.032*

 α1 globulin (1.1–3.7%)

2.17 ± 0.52

2.46 ± 1.45

0.328

 α2 globulin (8.5–14.5%)

9.05 ± 1.35

8.97 ± 1.40

0.843

 βglobulin (8.6–14.8%)

8.92 ± 1.51

8.97 ± 2.22

0.926

 γglobulin (9.2–18.2%)

12.95 ± 3.13

16.87 ± 6.35

0.023*