Table 1 Baseline characteristics of single acute infarction (lacunar infarction and non-lacunar infarction) and multiple acute infarctions
Characteristics | Single acute infarction:lacunar infarction n = 381 | Single acute infarction: non-lacunar infarction n = 172 | Multiple acute infarctions n = 281 | P value |
|---|---|---|---|---|
Age,y, median (IQR) | 62.6 (54.6–70.5) | 61.0 (54.1–70.1) | 64.8 (56.3–73.0) | 0.008 |
Male, n (%) | 261Â (68.5) | 105Â (61.0) | 193Â (68.7) | 0.17 |
Body mass index (kg/m2) | 24.5 (22.7–26.2) | 24.2 (22.0–26.6) | 24.2 (22.0–26.2) | 0.37 |
Medical history, n (%) | ||||
 Ischemic stroke | 63 (16.5) | 27 (15.7) | 54 (19.2) | 0.55 |
 TIA | 5 (1.3) | 4 (2.3) | 9 (3.2) | 0.25 |
 Myocardial infarction | 6 (1.6) | 4 (2.3) | 9 (3.2) | 0.38 |
 Angina | 9 (2.4) | 0 (0.0) | 9 (3.2) | 0.07 |
 Congestive heart failure | 2 (0.5) | 2 (1.2) | 10 (3.6) | 0.009 |
 Hypertension | 243 (63.8) | 109 (63.4) | 184 (65.5) | 0.87 |
 Diabetes mellitus | 77 (20.2) | 35 (20.3) | 69 (24.6) | 0.36 |
 Hypercholesterolaemia | 45 (11.8) | 20 (11.6) | 32 (11.4) | 0.99 |
Current or previous smoking, n (%) | 179Â (47.0) | 62Â (36.0) | 129Â (45.9) | 0.046 |
Time to randomization, n (%) | Â | Â | Â | 0.025 |
  < 12 h | 160 (42.0) | 88 (51.2) | 145 (51.6) |  |
  ≥ 12 h | 221 (58.0) | 84 (48.8) | 136 (48.4) |  |
NIHSS on admission, median(IQR) | 2.0 (1.0–3.0) | 2.0 (2.0–3.0) | 2.0 (1.0–3.0) | < 0.001 |
TOAST classification, n (%) |  |  |  | < 0.001 |
 Large-artery atherosclerosis | 127 (33.3) | 82 (47.7) | 183 (65.1) |  |
 Small-artery occlusion | 254 (66.7) | 0 (0.0) | 0 (0.0) |  |
 Undetermined cause | 0 (0.0) | 90 (52.3) | 98 (34.9) |  |
Group, n (%) | Â | Â | Â | 0.54 |
 Aspirin only | 195 (51.2) | 89 (51.7) | 133 (47.3) |  |
 Clopidogrel+aspirin | 186 (48.8) | 83 (48.3) | 148 (52.7) |  |
Medications, n (%) | ||||
 Antihypertensive | 126 (52.5) | 52 (48.2) | 79 (42.9) | 0.15 |
 Antidiabetic | 37 (48.1) | 17 (48.6) | 30 (43.5) | 0.82 |
 Lipid-lowering | 25 (56.8) | 14 (70.0) | 20 (62.5) | 0.60 |