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Table 1 Comparison of the futile reperfusion group and the no-futile reperfusion group after successful reperfusion

From: Futile reperfusion and predicted therapeutic benefits after successful endovascular treatment according to initial stroke severity

 

Futile reperfusion (3-month mRS 3–6 with TICI grade 2b–3) n = 226

No-futile reperfusion (3-month mRS 0–2 with TICI grade 2b–3) n = 214

P-value

Age, mean ± SD

70.3 ± 12.1

64.0 ± 11.8

0.08d

Male, %

120 (53.1)

135 (63.1)

0.04a

TOAST

  

0.96a

 LAA

51 (22.6)

50 (23.4)

 

 CE

131 (58.0)

121 (56.5)

 

 others

44 (19.5)

43 (20.1)

 

Hypertension, %

151 (66.8)

122 (57.0)

0.04a

Diabetes mellitus, %

58 (25.7)

42 (19.6)

0.14a

Hyperlipidemia, %

46 (20.4)

47 (22.0)

0.73a

Current Smoking, %

37 (16.4)

62 (29.0)

0.002a

Atrial fibrillation, %

120 (53.1)

108 (50.5)

0.63a

NIHSS, IQR

16 (12–19)

12 (8–17)

< 0.001c

 NIHSS ≤5

9 (4.0)

34 (15.9)

< 0.001a

 NIHSS 6~10

28 (12.4)

53 (24.8)

 

 NIHSS 11~20

152 (67.3)

106 (49.5)

 

 NIHSS > 20

37 (16.4)

21 (9.8)

 

Pre-stroke antithrombotics, %

83 (36.7)

93 (43.5)

0.17a

Pre-stroke statin, %

46 (20.4)

46 (21.5)

0.82a

SBP, mean ± SD

143.7 ± 27.3

138.4 ± 27.0

0.92d

Creatinine, mg/dL, mean ± SD

0.97 ± 0.48

0.92 ± 0.28

0.02d

Total cholesterol, mg/dL, mean ± SD

165.4 ± 39.7

166.1 ± 40.6

0.84d

Initial random glucose,

mg/dL, mean ± SD

139.5 ± 49.2

130.0 ± 41.5

0.20d

Preceding IVT, %

154 (68.1)

154 (72.0)

0.41a

Onset to EVT start time, min, mean ± SD

257.4 ± 110.9

245.3 ± 124.0

0.18d

Location of occlusion, %

  

0.66a

 MCA

119 (52.7)

122 (57.0)

 

 ICA

56 (24.8)

49 (22.9)

 

 MCA + ICA

51 (22.6)

43 (20.1)

 

Location of lesions, %

 Right hemisphere

110 (48.7)

110 (51.4)

0.64a

 Left hemisphere

111 (49.1)

97 (45.3)

 

 Both hemisphere

5 (2.2)

7 (3.3)

 

Symptomatic HT

20 (8.8)

6 (2.8)

< 0.001b

Neurologic progression*

40 (17.7)

22 (10.3)

< 0.001b

  1. * Neurologic progression was defined as 1) deterioration attributable to progressive ischemia, swelling of infarcted tissue or perilesional edema in patients who were stable neurologically during 24 h or more, 2) not attributable to stroke recurrence, symptomatic hemorrhage transformation or medical illness, and 3) an increase of total NIHSS scores 2 or more or an increase in the NIHSS subscale related to level of consciousness or motor subscale
  2. Abbreviation: SD standard deviation, mRS modified Rankin scale, TICI Thrombolysis in Cerebral Infarction, LAA large artery atherosclerosis, CE cardiac embolism, NIHSS National Institutes of Health Stroke Scale, IQR interquartile range, SBP systolic blood pressure, IVT intravenous thrombolysis, EVT endovascular treatment, MCA middle cerebral artery, ICA internal carotid artery, HT hemorrhagic transformation
  3. a Calculated by chi-squared test
  4. b Calculated by Fisher exact test
  5. c Calculated by Mann-Whitney U test
  6. d Calculated by Student’s t-test