Table 2 Genotypic distribution of the t-PA and PAI-1 gene between TLE patients and controls
From: Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population
Gene | SNP | Genotype | Cases (242 alleles across 121 subjects) n (% of population) | Controls (292 alleles across 146 subjects) n (% of population) | OR(95%CI) | χ2 | p-valuea | p-valueb |
|---|---|---|---|---|---|---|---|---|
t-PA | rs2020918 | CC | 61(50.4) | 98(67.1) | Â | Â | Â | Â |
CT | 49(40.5) | 41(28.1) | Â | Â | Â | Â | ||
TT | 11(9.1) | 7(4.8) | Â | 7.939 | 0.019a | 0.057b | ||
CT + TT | 60(49.6) | 48(32.9) | 2.008(1.223–3.298) | 7.670 | 0.006 |  | ||
rs4646972 | 311 bp/311 bp | 30(24.8) | 64(43.8) |  |  |  |  | |
311 bp/− | 52(43.0) | 57(39.1) |  |  |  |  | ||
−/− | 39(32.2) | 25(17.1) |  | 13.366 | 0.001a | 0.003b | ||
311 bp/− + −/− | 91(75.2) | 82(56.2) | 0.422(0.250–0.715) | 10.517 | 0.001 |  | ||
PAI-1 | rs1799768 | GG | 20(16.5) | 27(18.5) | Â | Â | Â | Â |
−/G | 63(52.1) | 69(47.3) |  |  |  |  | ||
−/− | 38(31.4) | 50(34.2) |  | 0.616 | 0.735 |  |