Skip to main content

Table 2 Genotype distribution of patients with or without carotid stenosis (n, %)

From: The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke

 

carotid stenosis (n = 236)

Non-carotid stenosis (n = 378)

P value

ORa (95% CI)

TXA2R (rs1131882)

 CC

62 (26.3)

132 (34.9)

0.024

1.21 (0.95–1.98)

 CT

105 (44.5)

175 (46.3)

  

 TT

69 (29.3)

71 (18.8)

  

TXAS1 (rs2267679)

 CC

7 (3.0)

12 (3.2)

0.786

0.94 (0.71–1.63)

 CT

39 (16.5)

68 (18.0)

  

 TT

190 (80.5)

298 (78.8)

  

TXAS1 (rs194149)

 AA

39 (16.5)

63 (16.7)

0.673

0.83 (0.663–1.72)

 AG

118 (50.0)

181 (47.9)

  

 GG

79 (33.5)

134 (35.4)

  

TXAS1 (rs41708)

 GG

116 (49.2)

228 (60.3)

0.011

1.23 (0.58–2.34)

 GT

66 (27.9)

113 (29.9)

  

 TT

54 (22.9)

37 (9.8)

  

P2Y1(rs701265)

 AA

127 (53.8)

202 (53.4)

0.989

0.67 (0.82–1.24)

 AG

70 (29.7)

113 (29.9)

  

 GG

39 (16.5)

63 (16.7)

  

P2Y1(rs1439010)

 AA

127 (53.8)

202 (53.4)

0.886

0.93 (0.83–1.68)

 AG

71 (30.1)

113 (29.9)

  

 GG

38 (16.1)

63 (16.7)

  

P2Y1(rs1371097)

 CC

141 (59.7)

203 (53.7)

0.006

1.07 (0.96–2.18)

 CT

38 (16.1)

120 (31.7)

  

 TT

57 (24.2)

55 (14.6)

  

P2Y12(rs16863323)

 CC

59 (25.0)

102 (27.0)

0.155

0.95 (0.92–1.66)

 CT

66 (28.0)

132 (34.9)

  

 TT

111 (47.0)

144 (38.1)

  

P2Y12(rs9859538)

 GG

160 (67.8)

256 (67.7)

0.966

0.88 (0.67–1.45)

 AG

50 (21.2)

84 (22.2)

  

 AA

26 (11.0)

38 (10.1)

  

GPIIIa (rs2317676)

 AA

135 (57.2)

234 (61.9)

0.012

1.04 (0.76–2.14)

 AG

47 (19.9)

106 (28.2)

  

 GG

54 (22.9)

38 (10.1)

  

GPIIIa (rs11871251)

 AA

89 (37.7)

144 (38.1)

0.962

0.82 (0.53–1.37)

 AG

78 (33.1)

129 (34.1)

  

 GG

69 (29.2)

105 (27.8)

  
  1. OR odds ratio, CI confidence interval
  2. aOR adjusted for age, gender, hypertension, diabetes, smoking, hyperlipidemia, homocysteine and hemoglobin A1c