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Table 2 Changes in clinical assessments and vascular responses (in perfusion units) to acetylcholine and sodium nitroprusside in all patients (n = 24), and the subsequent time course of decay in acetylcholine response to 50% of the peak value at baseline and following 6 months of treatment. Values are means ± SE

From: Peripheral vascular responses to acetylcholine as a predictive tool for response to cholinesterase inhibitors in Alzheimer’s disease

  Baseline 6 months
Clinical parameters
 MMSE 24.0 ± 0.6 24.7 ± 0.6
 NOSGER IADL/SB 37.8 ± 1.6 37.5 ± 1.7
 NOSGER Total 118.9 ± 3.7 118.7 ± 3.3
 DSST 21.4 ± 2.3 21.9 ± 2.1
Vascular responses
 Basal perfusion (PU) 40 ± 11 47 ± 12
 Peak acetylcholine response (PU) 334 ± 40 389 ± 31
 Peak sodium nitroprusside response (PU) 274 ± 34 337 ± 33
 Acetylcholine 50% decay (secs) 318 ± 41 321 ± 32
  1. MMSE Mini Mental State Exam
  2. NOSGER Nurses Observation Scale for Geriatric Patients IADL/SB combined score (max 50, higher scores are better)
  3. NOSGER Total Nurses Observation Scale for Geriatric Patients Total Score (max 150, higher scores are better)
  4. DSST Digit Symbol Substitution Test over 90 s