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Table 3 Summary of capacity for work as measured by WPAI at 1 and 2 years

From: Outcomes of natalizumab treatment within 3 years of relapsing-remitting multiple sclerosis diagnosis: a prespecified 2-year interim analysis of STRIVE

WPAI assessment

Baseline

1 year

2 years

 

Score, mean (SD)

Score, mean (SD)

Change from baseline, mean (95% CI)

p-value

Score, mean (SD)

Change from baseline, mean (95% CI)

p-value

Hours missed from work per week because of MS

5.4 (12.73)

1.9 (6.10)

−1.69 (−3.57, 0.18)

0.076

1.5 (4.66)

−2.84 (−5.29, − 0.38)

0.024

(n = 144)

(n = 126)

(n = 108)

 

(n = 109)

(n = 87)

 

Hours missed from work per week for non-MS reasons

2.9 (5.61)

3.3 (7.09)

0.57 (−1.09, 2.22)

0.498

2.9 (5.80)

−0.73 (−2.35, 0.89)

0.373

(n = 147)

(n = 126)

(n = 112)

 

(n = 109)

(n = 92)

 

Hours worked per week

33.1 (16.30)

31.9 (15.10)

−1.53 (−4.68, 1.61)

0.336

33.9 (14.64)

2.38 (−1.00, 5.76)

0.166

(n = 146)

(n = 124)

(n = 108)

 

(n = 112)

(n = 94)

 

Work productivity affected by MSa

2.6 (2.62)

2.2 (2.52)

−0.15 (−0.62, 0.31)

0.515

2.3 (2.54)

−0.21 (− 0.83, 0.41)

0.500

(n = 144)

(n = 125)

(n = 110)

 

(n = 111)

(n = 95)

 

Regular activities affected by MSb

3.7 (2.96)

3.3 (3.05)

−0.37 (− 0.79, 0.04)

0.078

3.0 (2.98)

−0.61 (−1.08, − 0.14)

0.011

(n = 218)

(n = 187)

(n = 185)

 

(n = 150)

(n = 148)

 
  1. CI confidence interval, MS multiple sclerosis, SD standard deviation, WPAI Work Productivity and Activity Impairment Questionnaire
  2. p-values are for change from baseline and are based on a paired t-test. Statistically significant p-values are shown in bold
  3. aPatients were asked “During the past 7 days, how much did your problem affect your productivity while you were working?” Patients provided an answer from 0 to 10, with 0 indicating that the problem had no effect on their work and 10 indicating that the problem completely prevented them from working
  4. bPatients were asked “During the past 7 days, how much did your problem affect your ability to do your regular daily activities, other than work at a job?” Patients provided an answer from 0 to 10, with 0 indicating that the problem had no effect on their daily activities and 10 indicating that the problem completely prevented them from doing their daily activities