Skip to main content

Table 4 Characteristics associated with mortality in patients with acute stroke during 3-months follow-up. HR (hazard ratio). The final model included n = 434 complete cases and 16 events. Median follow-up time was 94 days IQR: 90–101 days)a. Nagelkerke R2 = 0.18

From: Biomarkers of immune capacity, infection and inflammation are associated with poor outcome and mortality after stroke - the PREDICT study

Characteristic

HR

95% CI

p-value

Female sex

1.91

0.60–6.10

0.275

Age, yrs.

1.03

0.97–1.10

0.288

NIHSS categories

 0–4

1.0

  

 5–15

0.82

0.22–3.10

0.765

 16+

1.39

0.25–7.70

0.705

Pneumonia

5.43

1.22–24.11

0.026

Diabetes mellitus

0.74

0.19–2.88

0.660

Hypertension

0.63

0.15–2.88

0.529

Atrial Fibrillation

1.44

0.46–4.49

0.529

Biomarker

 LBP day 1b (pg/ml)

2.26

0.65–7.90

0.288

 mHLA-DRb (pg/ml)

0.53

0.13–2.07

0.359

 IL6b (pg/ml)

1.97

1.05–3.70

0.034

 IL10 (> 5) (pg/ml)

1.02

0.27–3.81

0.979

AUC survival Cox regression model without biomarkers at day 1

  

0.76 (0.61–0.90)

AUC survival Cox regression model with biomarkers at day 1

  

0.81 (0.68–0.94)

  1. aAnalysis was restricted to patients without missing values for the respective variables (N = 437). Variables were eliminated using backward elimination procedure, stepwise excluding all variables with p > 0.200. AUCs were calculated with a cut-off in follow-up time at 90 days.434). Cox regression stratified by centers
  2. blog-transformed