Skip to main content

Table 2 Outcome measures and tests

From: Cerebellar transcranial direct current stimulation in spinocerebellar ataxia type 3 (SCA3-tDCS): rationale and protocol of a randomized, double-blind, sham-controlled study

Outcome domain

Test

Time point

Primary outcome measure

 Cerebellar ataxia severity

SARA (absolute change from baseline)

T1

Secondary outcome measures

 Cerebellar ataxia severity

SARA (% of patients with a decrease of ≥ 1.5 points)

T1

 Cerebellar ataxia severity

SARA score and subscores

T0 after tDCS, T2-T4

 Gait speed

8 m walk test

T0 after tDCS, T1-T4

 Articulation speed

PATA repetition rate

T0 after tDCS, T1-T4

 Upper limb dexterity

9-hole peg test

T0 after tDCS, T1-T4

 Extracerebellar signs

INAS count

T1-T4

 Postural sway

Static posturography

T0 after tDCS and T1

 Quality of life

EQ-5D-5L

T1-T4

 Depression

PHQ-9

T1-T4

 Mood states

POMS 32-item version

T1-T4

 Cognition and affect

CCAS scale (total score and number of ‘fails’)

T1-T4

 Activities of daily living

FARS part II

T1-T4

 Medical consumption

iMCQ

T4

 Motor learning

Delay EBC (acquisition of CRs)

T1

 CBI

Transcranial magnetic stimulation

T1

 tDCS-related side effects

Open question

T1

 Correct randomization

Patients’ thoughts about treatment allocation

T1

  1. SARA Scale for the Assessment and Rating of Ataxia, INAS Inventory of Non-Ataxia Signs, EQ-5D-5L  EuroQol 5-Dimension 5-Level, PHQ-9 Patient Health Questionnaire-9, POMS Profile of Mood States, CCAS Cerebellar Cognitive Affective Syndrome, FARS Friedreich Ataxia Rating Scale, iMCQ Institute for Medical Technology Assessment (iMTA) Medical Consumption Questionnaire, EBC Eyeblink conditioning; CR Conditioned response, CBI Cerebellar brain inhibition