Fig. 1From: Adult-onset vanishing white matter disease with the EIF2B2 gene mutation presenting as menometrorrhagiaNeuroimaging results of the VWMD patient. a Axial T1-weighted, T2-weighted, Flair, DWI, ADC and coronal T1-weighted images showing extensive cerebral white matter abnormalities with central areas resembling signal intensity of cerebrospinal fluid surrounded by a rim of hyperintensity in the periventricular and subcortical regions. White-matter rarefaction and cystic degeneration are more evident in subcortical and periventricular regions. Obvious brain atrophy was also detected. b Brain 18F-FDG PET showed decreased FDG uptake in left frontal, parietal and temporal lobe. Compared with right side, the decline rate is 17, 12 and 17%. c Brain DTI disclosed fibrous white bundle was reduced sparsely among bilateral periventricularBack to article page