Table 1 Clinical characteristics of the study participants
Clinical characteristics | Total participants | Spinal onset | Bulbar onset | p value |
|---|---|---|---|---|
(n = 24) | (n = 21) | |||
(n = 45) | ||||
Age at onset (years), mean (range) | 58.11 (38–82) | 55.96 (42–82) | 60.57 (38–81) | 0.1566 |
Age at diagnosis (years), mean (range) | 58.89 (40–83) | 58.17 (43–83) | 61.86 (40–81) | 0.2432 |
Gender | ||||
Males, n (%) | 20 (44.44) | 12 (50) | 8 (38.09) | 0.4227 |
Females, n (%) | 25 (55.55) | 12 (50) | 13 (61.90) | |
Weight at diagnosis (Kg), mean (SD) | 50.11 (12.06) | 48.61 (12.18) | 51.07 (12.34) | 0.6536 |
Family history of ALS, n (%) | 2 (4.44) | 1 (4.16) | 1 (4.76) | 0.4227 |
Comorbidities, n (%) | 13 (28.88) | 6 (25) | 7 (33.33) | 0.9230 |
SAH, n (%) | 8 (17.77) | 4 (16.66) | 4 (19.04) | 0.5384 |
Ischemic cardiopathy, n (%) | 3 (6.66) | 1 (4.16) | 2 (9.52) | 0.8349 |
Hypothyroidism, n (%) | 2 (4.44) | 1 (4.16) | 0 (0) | 0.4723 |
Diabetes, n (%) | 1 (2.22) | 1 (4.16) | 0 (0) | 0.4723 |
Cancer, n (%) | 1 (2.22) | 0 (0) | 1 (4.76) | 0.2796 |
Rheumatoid arthritis, n (%) | 1 (2.22) | 0 (0) | 1 (4.76) | 0.2796 |
Gout, n (%) | 1 (2.22) | 1 (4.16) | 0 (0) | 0.4723 |
Weight loss (Kg), mean (SD) | 11.79 (6.12) | 10.83 (4.44) | 11.76 (8.29) | 0.8334 |
Survival time from onset (mo), mean (SD) | 64.73 (34.83) | 73.96 (35.60) | 54.19 (31.51) | 0.0565 |
ODI (mo), mean (SD) | 22.22 (16.51) | 27.50 (19.96) | 16.19 (8.34) | 0.0483 |
DDI (mo), mean (SD) | 42.51 (28.44) | 46.46 (30.34) | 38 (26.09) | 0.3252 |
PEG, n (%) | 31 (68.88) | 17 (70.83) | 14 (66.66) | 0.5384 |
OGI (mo), mean (SD) | 18.61 (18.03) | 20.47 (21.65) | 16.36 (12.79) | 0.9291 |
GDI (mo), mean (SD) | 44.90 (28.50) | 48.88 (31.74) | 40.07 (24.27) | 0.4009 |
MV, n (%) | 32 (71.11) | 18 (75) | 14 (66.66) | 0.4723 |
OMVI (mo), mean (SD) | 26.84 (25.12) | 34.94 (30.40) | 16.43 (9.37) | 0.0266 |
MVDI (mo), mean (SD) | 29.69 (24.41) | 28.33 (21.95) | 31.43 (28.03) | 0.8880 |
Cause of death | ||||
Respiratory failure, n (%) | 28 (62.22) | 17 (70.83) | 11 (52.38) | 0.2028 |
Pneumonia, n (%) | 11 (24.44) | 4 (16.66) | 7 (33.33) | 0.1943 |
Sudden cardiac arrest, n (%) | 3 (6.66) | 1 (4.16) | 2 (9.52) | 0.4723 |
Myocardial infarction, n (%) | 2 (4.44) | 1 (4.16) | 1 (4.76) | 0.4227 |
Abdominal sepsis, n (%) | 1 (2.22) | 1 (4.16) | 0 (0) | 0.4723 |
Total cholesterol levels at onset (mmol/L), mean (SD)a | 4.63 (1.11) | 4.66 (1.29) | 4.58 (0.86) | 0.8588 |