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Table 2 Odds ratio (OR) with 95% confidence interval (CI) of high sensitivity C-reactive protein (hs-CRP) defined as > 3.0–20.0 mg/l related to headache types

From: The impact of C-reactive protein levels on headache frequency in the HUNT study 2006–2008

  Total High hs-CRP Model 1 Model 2 Model 3
N OR (95% CI) OR (95% CI) OR (95% CI)
No headache 24,823 5179 1.00 1.00 1.00
Any headache 13,990 3029 1.11 (1.05–1.17) 1.07 (1.01–1.13) 1.05 (1.00–1.11)
 < 1 days/month 3176 581 1.02 (0.95–1.11) 0.99 (0.91–1.07) 0.97 (0.90–1.08)
 1–6 days/month 8099 1761 1.06 (0.99–1.13) 1.01 (0.95–1.08) 0.99 (0.93–1.07)
 7–14 days/month 1731 425 1.28 (1.14–1.44) 1.21 (1.08–1.37) 1.15 (1.04–1.30)
 ≥ 15 days/month 984 262 1.40 (1.21–1.62) 1.32 (1.13–1.53) 1.26 (1.08–1.48)
 P trend    < 0.001 0.001 0.01
Migraine 3793 864 1.23 (1.13–1.34) 1.17 (1.07–1.28) 1.14 (1.04–1.25)
 < 1 days/month 599 115 0.99 (0.89–1.10) 0.94 (0.84–1.05) 0.92 (0.82–1.02)
 1–6 days/month 2340 526 1.19 (1.07–1.31) 1.12 (1.01–1.25) 1.10 (1.00–1.23)
 7–14 days/month 625 152 1.36 (1.12–1.64) 1.32 (1.09–1.60) 1.24 (1.02–1.51)
 ≥ 15 days/month 229 71 1.88 (1.42–2.50) 1.72 (1.29–2.31) 1.62 (1.21–2.17)
 P trend    < 0.001 < 0.001 0.01
MA 2139 509 1.26 (1.13–1.40) 1.24 (1.11–1.39) 1.15 (1.03–1.29)
 < 1 days/month 320 65 1.01 (0.90–1.13) 0.95 (0.85–1.07) 0.93 (0.82–1.04)
 1–6 days/month 1290 293 1.19 (1.05–1.35) 1.13 (0.99–1.28) 1.09 (0.96–1.24)
 7–14 days/month 391 105 1.56 (1.23–1.96) 1.51 (1.19–1.91) 1.40 (1.11–1.77)
 ≥ 15 days/month 138 46 2.15 (1.50–3.08) 2.01 (1.39–2.90) 1.84 (1.27–2.67)
 P trend    < 0.001 < 0.001 0.002
MO 1654 355 1.17 (1.03–1.32) 1.12 (0.99–1.27) 1.09 (0.96–1.24)
 < 1 days/month 279 50 0.99 (0.88–1.11) 0.94 (0.84–1.06) 0.92 (0.82–1.04)
 1–6 days/month 1050 233 1.18 (1.03–1.35) 1.14 (0.99–1.31) 1.13 (0.98–1.30)
 7–14 days/month 234 47 1.10 (0.79–1.52) 1.08 (0.77–1.50) 1.03 (0.74–1.44)
 ≥ 15 days/month 91 25 1.58 (0.99–2.51) 1.42 (0.88–2.28) 1.37 (0.85–2.22)
 P trend    0.01 0.12 0.23
Other headaches 10,197 2165 1.08 (1.02–1.14) 1.04 (0.98–1.11) 1.04 (0.97–1.10)
 < 1 days/month 2577 534 1.05 (0.96–1.14) 1.01 (0.93–1.10) 1.00 (0.92–1.09)
 1–6 days/month 5759 1167 1.03 (0.96–1.11) 1.00 (0.93–1.07) 0.98 (0.91–1.05)
 7–14 days/month 17,106 273 1.28 (1.11–1.47) 1.20 (1.04–1.39) 1.15 (1.00–1.33)
 ≥ 15 days/month 755 191 1.29 (1.09–1.53) 1.23 (1.04–1.46) 1.18 (0.99–1.41)
 P trend    < 0.001 0.03 0.16
  1. MA Migraine with aura, MO Migraine without aura. Model 1: Adjusted for ag, and sex. Model 2: Adjusted for age, sex and body mass index. Model 3: Adjusted for age, sex, body mass index, smoking, employment status, alcohol use, physical activity and Hospital Anxiety and Depression Scale score