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Table 5 Associations a of Mid-Life (1990–1992) 25(OH) D Concentrations with Incident Dementia, the ARIC Study

From: Mid-life serum Vitamin D concentrations were associated with incident dementia but not late-life neuropsychological performance in the Atherosclerosis Risk in Communities (ARIC) Study

  25(OH) D (ng/mL) p-trend Per 1 SD decrement in 25(OH) D c
≥30 20- < 30 < 20
N 3046 5759 4234 13,039
Case, n (%) 271 (8.9%) 600 (10.4%) 452 (10.7%) 1323 (10.1%)
Incidence rate (95% CI) b 4.83 (4.29, 5.44) 5.73 (5.28, 6.20) 6.07 (5.54, 6.66) 5.62 (5.33, 5.93)
Model 1 d Reference [1] 1.12 (0.97, 1.30) 1.26 (1.06, 1.49) 0.01 1.05 (0.98, 1.12)
Model 2 e Reference [1] 1.12 (0.97, 1.30) 1.25 (1.05, 1.48) 0.01 1.04 (0.98, 1.12)
Model 3 f Reference [1] 1.12 (0.97, 1.30) 1.24 (1.05, 1.48) 0.01 1.04 (0.98, 1.11)
  1. a Results presented as Hazard Ratios (95% Confidence Intervals). Data in bold text are statistically significant, P < .05
  2. b unadjusted and per 1000 person-years
  3. c SD 25(OH) D = 8.4 ng/mL;To covert 25(OH) D from ng/mL to nmol/L, multiply by 2.496
  4. d Model 1: adjusted for age, sex, race/center, educational, body mass index, smoking status, alcohol consumption, physical activity, and APOE ε4 genotype
  5. e Model 2: Model 1 plus systolic blood pressure, use of hypertension medication, total and HDL cholesterol, use of cholesterol medications, diabetes, coronary heart disease, and estimated glomerular filtration rate
  6. f Model 3: Model 2 plus serum parathyroid hormone, calcium, and phosphorus concentrations