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Table 2 Biomarker characteristics

From: Amyloid PET, FDG-PET or MRI? - the power of different imaging biomarkers to detect progression of early Alzheimer’s disease

  Mean ± SD (Min - Max) Effect size (Cohen’s d) Minimal sample size (n)
FDG AD-ROIs/pons (BL) 1,28 ± 0.15 (1.01–1.51)   
Δ (FDG AD-ROIs/pons) within 24 months −0.05 ± 0.15 (− 0.37–0.32) 0.341 70
PiB global/cerebellar vermis (BL) 1.63 ± 0.22 (1.37–2.16)   
Δ (PiB global/cerebellar vermis) within 24 months 0.12 ± 0.09 (− 0.05–0.25) 1.315 7
Cortical thickness global (BL) [mm] 2.31 ± 0.23 (1.87–2.80)   
Δ Cortical thickness global within 24 months [mm] −0.14 ± 0.15 (− 0.45–0.11) 0.914 12
  1. SD Standard deviation, min Minimum, max Maximum, FDG 18F-fluordeoxyglucose, AD-ROIs Alzheimer’s disease signature regions of interest, BL At baseline, PiB 11C-Pittsburgh compound B, global Region of interest equals entire grey matter, Δ Changes between baseline and follow up adjusted to a 24 months follow up period, negative values indicate decrease, positive values indicate increase compared to BL