Table 1 Description of autoantibodies seen in neuronal surface antibody group, intracellular antibody group and coexisting-antibodies group
From: Differences and diversity of autoimmune encephalitis in 77 cases from a single tertiary care center
Antibodies | Number of serum positive patients | Number of CSF positive patients | Age range (year) | % Male | Presenting symptoms | Evidence of tumor at 1st screening (cases) |
|---|---|---|---|---|---|---|
Anti-NMDAr (25 cases) | 24 | 16 (8 N/A) | 5–79 | 44.1 | Behavior, psychosis, dyskinesia, seizures, memory impairment, catatonia, mood disorders | Ovarian tumor [3] |
Anti-AMPAr (2 cases) | 2 | 1 (1 N/A) | 2–72 | 50.0 | Behavior, stiff-person syndrome | NSCLC [1] |
Anti-GABA-Br (2 cases) | 2 | 1 (1 N/A) | 42–70 | 50.0 | Behavior, seizures, myoclonus | Stomach cancer [1] |
Anti-LGI1 (2 cases) | 2 | 1 (1 N/A) | 67–75 | 50.0 | Behavior, seizures, FBDS | None |
Anti-Ri (ANNA2) (7 cases) | 7 | 1 (6 N/A) | 44–82 | 42.9 | Seizures, psychosis, dyskinesia, weakness | None |
Anti-Yo (PCA1) (3 cases) | 3 | 1 (2 N/A) | 11–31 | 66.7 | Seizures, diplopia, drowsiness, weakness | Germ cell tumor [1], high CA-125 (1) |
Anti-PNMA2 (3 cases) | 3 | 1 (1 N/A) | 35–80 | 66.7 | Behavior, dyskinesia, rapidly progressive dementia, weakness | Pancreatic cancer [1],high CA-125 (1) |
Anti-recoverin (3 cases) | 3 | 0 | 40–71 | 66.7 | Behavior, ataxia, numbness | None |
Anti-CV2 (CRMP5) (2 cases) | 2 | 1 (1 N/A) | 59–65 | 50.0 | Psychosis, memory impairment | Ovarian cancer [1] |
Anti-Hu antibody (2 cases) | 2 | N/A | 28–29 | 0.0 | Behavior, seizures, weakness, numbness | None |
Anti-GAD65 (2 cases) | 2 | 1 (1 N/A) | 1–16 | 50.0 | Seizures, opsoclonus-myoclonus, ataxia | Neuroblastoma [1] |
Anti-SOX1 (2 cases) | 2 | 2 | 33–66 | 50.0 | Behavior, dyskinesia | None |
Anti-titin (1 case) | 1 | 0 | 86 | 0:0 | Drowsiness, psychomotor retardation | None |
Anti-NMDAr +ANA (2 cases) | 2 | 2 | 15–30 | 0:0 | Behavior, psychosis, seizures | Ovarian tumor [1] |
Anti-NMDAr +anti-Ri (1 case) | 1 | N/A | 18 | 100.0 | Seizures | None |
Anti-NMDAr +AQP4 (1 case) | 1 | 1 | 24 | 0.0 | Behavior, dyskinesia, weakness | None |