Table 7 Functional roles of hub genes
NO. | Gene symbol | Full name | Function |
|---|---|---|---|
1 | TRP53 | Tumor protein P53 | TRP53 is a transcription factor which can regulate cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism |
2 | RRM2 | Ribonucleotide reductase regulatory subunit M2 | RRM2 is involved in catalyzing the formation of deoxyribonucleotides from ribonucleotides. |
3 | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B | RRM2B encodes the small subunit of a p53-inducible ribonucleotide reductase which is necessary for DNA synthesis. |
4 | RRM1 | Ribonucleotide reductase catalytic subunit M1 | RRM1 has been implicated in DNA replication as well as multiple DNA repair processes |
5 | VCP | Valosin containing protein | VCP is involved in protein degradation, intracellular membrane fusion, DNA repair and replication and activation of the NF-kappa B pathway |
6 | MPP4 | Membrane palmitoylated protein 4 | MPP4 is associated with photoreceptor polarity and the organization of specialized intercellular junctions |