Table 2 Univariable analysis of potential the risk factors for predicting the prognosis of NMOSD
Factor | Statistical value | Relapse | Final EDSS | ||
|---|---|---|---|---|---|
HR (95% CI) | P value | β (95% CI) | P value | ||
Male sex - no. (%) | 27 (24.77) | 0.71 (0.35, 1.42) | 0.331 | 0.06 (−0.72, 0.83) | 0.887 |
Age (years) | 42.21 ± 15.45 | 1.00 (0.99, 1.02) | 0.699 | 0.00 (− 0.02, 0.03) | 0.754 |
Hypertension - no. (%) | 13 (11.93) | 2.76 (1.37, 5.56) | 0.004* | −0.17 (−1.20, 0.87) | 0.754 |
Diabetes - no. (%) | 7 (6.42) | 1.64 (0.65, 4.14) | 0.293 | −0.15 (− 1.51, 1.21) | 0.830 |
Initial EDSS | 4.89 ± 1.80 | 0.95 (0.82, 1.11) | 0.536 | 0.36 (0.19, 0.53) | < 0.001* |
Vision (EDSS of vision) | 1.71 ± 1.98 | 1.05 (0.91, 1.21) | 0.491 | 0.01 (−0.15, 0.18) | 0.866 |
Anti-AQP-4 antibody - no. (%) | |||||
Not tested | 30 (27.52) | 1.0 | |||
Negative | 30 (27.52) | 0.72 (0.33, 1.57) | 0.413 | 0.03 (−0.86, 0.92) | 0.942 |
Positive | 49 (44.95) | 1.20 (0.64, 2.23) | 0.569 | 0.69 (−0.11, 1.49) | 0.094 |
Autoimmune - no. (%) | 5 (4.59) | 1.98 (0.61, 6.41) | 0.256 | 0.56 (−1.04, 2.15) | 0.495 |
Corticosteroid - no. (%) | 95 (87.16) | 1.06 (0.51, 2.21) | 0.881 | 0.53 (−0.46, 1.52) | 0.299 |
IVIG - no. (%) | 5 (4.59) | 0.91 (0.22, 3.73) | 0.891 | 1.29 (−0.29, 2.87) | 0.112 |
Immunosuppressant - no. (%) | 26 (23.85) | 1.41 (0.76, 2.62) | 0.272 | −0.42 (−1.20, 0.36) | 0.295 |
Rehabilitation - no. (%) | 23 (21.1) | 1.24 (0.65, 2.37) | 0.510 | 0.19 (−0.63, 1.01) | 0.653 |
FT3 - pmol/L | 4.55 ± 0.83 | 0.96 (0.69, 1.34) | 0.827 | 0.20 (−0.21, 0.60) | 0.343 |
FT4 - pmol/L | 11.46 ± 2.49 | 1.16 (1.04, 1.28) | 0.006* | 0.19 (0.06, 0.32) | 0.006* |
TSH -μIU/mL | 3.21 ± 9.39 | 0.98 (0.93, 1.03) | 0.419 | −0.02 (−0.06, 0.01) | 0.216 |