Table 7 Frequency1 of impact on daily life of myasthenia gravis treatment2 by refractory group
From: Understanding side effects of therapy for myasthenia gravis and their impact on daily life
Impact Statement | Refractory with IVIg (n = 30) mean (SD) | Refractory without IVIg (n = 71) mean (SD) | Non-Refractory (n = 20) mean (SD) | P value3 |
|---|---|---|---|---|
1. To become depressed. | 2.3 (0.8) | 2.0 (0.9) | 1.7 (0.7) | 0.036 |
2. Affected my ability to work or attend school. | 2.9 (1.0) | 2.2 (1.1) | 1.6 (0.9) | <.001 |
3. Made me moody. | 2.5 (1.0) | 2.1 (0.9) | 1.6 (0.7) | 0.001 |
4. Caused me to sleep more than usual. | 2.2 (1.0) | 1.7 (1.0) | 1.6 (0.8) | 0.063 |
5. Caused me to discontinue or avoid taking my medications. | 1.9 (1.1) | 1.8 (1.0) | 1.6 (1.1) | 0.520 |
6. Caused insomnia or interferes with my sleep. I am not able to get a good night’s sleep. | 2.8 (1.0) | 2.5 (1.1) | 1.8 (1.0) | 0.008 |
7. Caused me to require additional medical procedures. | 1.8 (1.1) | 1.5 (0.8) | 1.3 (0.8) | 0.083 |
8. Interfered with my ability to care for my family. | 2.6 (1.1) | 2.0 (1.0) | 1.4 (0.7) | <.001 |
9. Made me very frustrated and/or demoralized. | 2.6 (0.9) | 2.1 (1.0) | 1.6 (0.9) | 0.004 |
10. Caused me to visit the emergency room and/or be hospitalized. | 2.0 (0.9) | 1.5 (0.8) | 1.1 (0.2) | <.001 |
11. Sometimes made my MG symptoms worse. | 1.9 (0.8) | 1.7 (0.8) | 1.5 (0.7) | 0.185 |
12. Have limited my daily activities. | 2.7 (1.1) | 2.2 (1.0) | 1.6 (0.9) | 0.002 |
13. Have limited me physically. | 3.0 (1.0) | 2.4 (1.2) | 1.9 (1.0) | 0.001 |
14. Made me very irritable and short-tempered. | 2.3 (0.9) | 1.9 (1.0) | 1.4 (0.7) | 0.004 |
15. With the MG treatment that I’m prescribed it is difficult to adjust the correct dose that I need to control my MG symptoms. | 2.0 (1.1) | 1.7 (0.9) | 1.5 (0.8) | 0.109 |
16. Have made me feel very self-conscious, ugly, and/or unattractive. | 2.3 (1.2) | 1.9 (1.1) | 1.6 (0.9) | 0.043 |
17. Made me uncomfortable being around other people. | 2.4 (1.0) | 1.9 (1.0) | 1.4 (0.7) | 0.006 |
18. Made me worry about catching infections from other people. | 2.5 (1.1) | 2.5 (1.0) | 1.7 (1.2) | 0.006 |
19. Have limited my mobility, | 2.7 (1.1) | 2.2 (1.1) | 1.6 (1.0) | 0.002 |
20. Have caused me to be so tired, I avoid leaving the house or going out in public. | 2.5 (1.0) | 2.0 (1.0) | 1.6 (0.9) | 0.006 |
21. Decreased my quality of life. | 2.8 (1.0) | 2.3 (1.0) | 1.6 (0.9) | <.001 |
22. Side effects sometimes caused me to have to choose between tolerating my MG symptoms or the side effects of medication. | 2.3 (1.1) | 1.9 (1.0) | 1.6 (1.0) | 0.059 |
23. Made life very stressful and/or overwhelming. | 2.6 (1.0) | 1.9 (1.1) | 1.5 (0.7) | <.001 |