Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis

Imani, Danyal; Razi, Bahman; Motallebnezhad, Morteza; Rezaei, Ramazan

doi:10.1186/s12883-019-1577-y

Table 2 Distribution of genotype and allele among MS patients and controls

From: Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis

Study author	MS cases					Healthy control					P-HWE	MAF
Study author	FF	Ff	ff	F	f	FF	Ff	Ff	F	f	P-HWE	MAF
FokI (rs2228570)
Partridge et al.	155	196	55	506	306	83	105	46	271	197	0/22	0/42
Tajouri et al.	47	40	11	134	62	34	48	11	116	70	0/33	0/376
Smolders et al.	79	103	30	261	163	113	134	42	360	218	0/82	0/377
Dickinson et al.	58	61	17	177	95	86	110	39	282	188	0/72	0/4
Simon et al.	36	45	19	117	83	41	44	15	126	74	0/57	0/37
Garcia-Martin et al.	130	141	32	401	205	144	124	42	412	208	0/07	0/335
Al-Temaimi et al.	33	14	3	80	20	33	16	1	82	18	0/55	0/18
Narooie-Nejad et al.	73	32	8	178	48	93	29	0	215	29	0/13	0/118
Cierny et al.	96	143	31	335	205	118	143	42	379	227	0/89	0/374
Luisa Agnello et al.	34	52	18	120	88	29	36	10	94	56	0/82	0/373
Abdollahzadeh et al.	14	67	79	95	225	11	59	80	81	219	0/97	0/73
Yucel et al.	22	6	1	50	8	72	34	8	178	50	0/16	0/219
Bettencourt et al.	223	227	83	673	393	204	197	45	605	287	0/79	0/321
Kamisli et al.	75	77	15	227	107	94	46	6	234	58	0/92	0/198
Sadeghi et al.	47	32	1	126	34	20	26	4	66	34	0/26	0/34
Křenek et al.	102	145	49	349	243	37	74	24	148	122	0/21	0/451
Study author	MS cases					Healthy control					P-HWE	MAF
Study author	TT	Tt	tt	T	t	TT	Tt	tt	T	T
TaqI (rs731236)
Partridge et al.	140	203	59	483	321	86	106	39	278	184	0/51	0/398
Tajouri et al.	27	57	20	111	97	104	42	40	250	122	0/57	0/327
Smolders et al.	83	96	33	262	162	112	138	39	362	216	0/53	0/373
Dickinson et al.	52	68	16	172	100	86	108	41	280	190	0/48	0/4
Simon et al.	40	50	10	130	70	36	48	16	120	80	1	0/4
Sioka et al.	30	30	9	90	48	33	36	12	102	60	0/67	0/37
Agliardi et al.	219	308	114	746	536	220	249	89	689	427	0/19	0/375
Irizar et al.	55	70	11	180	92	145	157	35	447	227	0/43	0/336
Garcia-Martin et al.	129	129	45	387	219	131	144	35	406	214	0/62	0/345
Selma et al.	28	29	3	85	35	75	38	1	188	40	0/1	0/175
Narooie-Nejad et al.	9	44	60	62	164	94	26	2	214	30	0/89	0/122
Al-Temaimi et al.	31	19	0	81	19	15	28	7	58	42	0/29	0/42
Yamout et al.	19	23	8	61	39	32	48	19	112	86	0/89	0/434
Cierny et al.	94	138	38	326	214	125	123	55	373	233	0/01	0/384
Luisa Agnello et al.	35	48	21	118	90	23	40	12	86	64	0/43	0/426
Terzi et al.	30	43	14	103	71	48	43	9	137	61	0/85	0/308
Abdollahzadeh et al.	38	80	42	156	164	63	68	19	194	106	0/92	0/353
Yucel et al.	13	15	0	41	15	31	26	15	88	56	0/05	0/388
Kamisli et al.	71	77	19	219	115	59	65	22	183	109	0/55	0/373
Morales et al.	65	46	9	176	64	122	41	17	285	75	0/005	0/208
Sadeghi et al.	38	41	1	117	43	14	34	2	62	38	0/02	0/38
Cakina et al.	20	41	9	81	59	20	45	5	85	55	0/001	0/392
Křenek et al.	118	151	27	387	205	58	66	11	182	88	0/19	0/325
Study author	MS cases					Healthy control					P-HWE	MAF
Study author	BB	Bb	bb	B	b	BB	Bb	bb	B	B	P-HWE	MAF
BsmI (rs1544410)
Fukazawa et al.	0	11	66	11	143	3	24	68	30	160	0/62	0/842
Qinli Sun et al.	0	7	56	7	119	0	11	84	11	179	0/54	0/942
Bing Wu et al.	0	5	78	5	161	0	26	94	26	214	0/18	0/891
Simon et al.	39	49	13	127	75	34	47	19	115	85	0/71	0/425
Sioka et al.	28	41	0	97	41	26	55	0	107	55	0/004	0/339
Al-Temaimi et al.	20	30	0	70	30	15	25	10	55	45	0/94	0/45
Narooie-Nejad et al.	59	50	4	168	58	45	65	12	155	89	0/09	0/364
Abdollahzadeh et al.	46	79	35	171	149	70	65	15	205	95	0/98	0/316
Yamout et al.	10	21	19	41	59	16	53	30	85	113	0/35	0/57
Cierny et al.	43	139	88	225	315	73	111	119	257	349	0/001	0/575
Luisa Agnello et al.	23	48	33	94	114	17	37	21	71	79	0/92	0/526
Terzi et al.	19	40	28	78	96	14	47	39	75	125	0/97	0/625
Morales et al.	60	38	22	158	82	110	60	10	280	80	0/63	0/222
Sadeghi et al.	12	51	17	75	85	16	29	5	61	39	0/12	0/39
Cakina et al..	14	36	20	64	76	11	37	22	59	81	0/48	0/578
Křenek et al.	114	153	29	381	211	61	63	11	185	85	0/34	0/314
Study author	MS cases					Healthy control					P-HWE	MAF
Study author	AA	Aa	aa	A	a	AA	Aa	aa	A	A
ApaI (rs7975232)
Niino et al.	21	23	33	65	89	9	41	45	59	131	0/93	0/689
Qinli Sun	9	17	37	35	91	15	29	51	59	131	0/005	0/689
Tajouri et al.	35	55	14	125	83	23	54	23	100	100	0/42	0/5
Smolders et al.	58	99	55	215	209	80	150	59	310	268	0/45	0/463
Bing Wu et al.	14	39	30	67	99	10	45	65	65	175	0/58	0/729
Simon et al.	29	45	26	103	97	28	50	22	106	94	0/97	0/47
Irizar et al.	39	60	35	138	130	76	178	86	330	350	0/37	0/514
Narooie-Nejad et al.	40	62	11	142	84	61	56	5	178	66	0/07	0/27
Al-Temaimi et al.	20	25	5	65	35	23	17	10	63	37	0/05	0/37
Selma et al.	14	36	10	64	56	40	58	16	138	90	0/48	0/394
Yamout et al.	19	22	9	60	40	33	51	15	117	81	0/51	0/503
Luisa Agnello et al.	31	58	15	120	88	26	41	8	93	57	0/16	0/38
Abdollahzadeh et al.	18	67	75	103	217	4	43	103	51	249	0/84	0/83
Cierny et al.	78	132	60	288	252	102	120	81	324	282	0/005	0/465
Terzi et al.	28	46	13	102	72	42	40	18	124	76	0/13	0/38
Yucel et al.	8	13	5	29	23	28	37	16	93	69	0/55	0/425
Kamisli et al.	62	76	29	200	134	54	67	25	175	117	0/59	0/4
Sadeghi et al.	22	53	5	97	63	23	22	5	68	32	0/93	0/32
Cakina et al..	28	27	15	83	57	20	21	29	61	79	0/001	0/564
Křenek et al.	27	183	86	237	355	31	78	26	140	130	0/07	0/481

P-HWE p-value for Hardy–Weinberg equilibrium, MAF minor allele frequency of control group

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