A prospective cohort study of MTHFR C677T gene polymorphism and its influence on the therapeutic effect of homocysteine in stroke patients with hyperhomocysteinemia

Table 3 Homocysteine levels before and after treatment according to MTHFR C677T genotype

	CC (n = 10)	CT (n = 55)	TT (n = 97)	P value^*
HCY before treatment, μmol/L	20.26 ± 6.60	18.90 ± 6.37	21.75 ± 8.19	0.049
HCY after treatment, μmol/L	14.02 ± 3.53	12.98 ± 5.01 ^ab	19.45 ± 11.32 ^ab	0.002
P value^**	0.535	0.328	0.211

^* Analysis of variance was used for comparison among genotypes
^** Paired sample t-test was used for comparison between baseline and 1 month after treatment
^ab Different letters indicate statistical significance. Least significant difference (LSD) test was used for pairwise comparison. CCvsCT p = 0.816; CC vs TT p = 0.215; CT vs TT p = 0.001

ISSN: 1471-2377