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Table 2 Data summary of Clinical Characteristics of of reported FXTAS cases

From: A Chinese case of fragile X-associated tremor/ataxia syndrome (FXTAS) with orthostatic tremor:case report and literature review on tremor in FXTAS

 Total(n = 64)Male (n = 44)Female (n = 20)P-valueb
Onset age (years old)60.5 (12.5)a59.0 (10.5)61.5 (14)0.376
Duration before diagnosis (years)5 .5(5.4)a4.8 (5.6)5.8 (5.2)0.026
Positive family history(%)44/59(74.6%)30/40(75.0)14/19(73.7%)0.905
Tremor(%)52/61(85.2%)33/41(80.5%)19/20(95.0%)0.135
Intention tremor(%)26/61(42.6%)15/41(36.6%)11/20(55.5%)0.171
Kinetic tremor(%)22/61(36.1%)17/41(41.5%)5/20(25.0%)0.209
Rest tremor(%)20/61(32.8%)13/41(31.7%)7/20(35.0%)0.802
Isolated rest tremor6/61(9.8%)2/41(4.9%)4/20(20.0%)0.063
Posture tremor(%)18/61(29.5%)12/41(29.3%)6/20(33.3%)0.952
Orthostatic tremor2/61(3.3%)1/41(2.4%)1/20(5.0%)0.603
voice tremor2/61(3.3%)1/41(2.4%)1/20(5.0%)0.603
Head tremor6/61(9.8%)3/41(7.3%)3/20(15%)0.346
More than two types of tremor(%)23/61(37.7%)17/41(41.5%)6/20(30.0%)0.386
Ataxia (%)52/64(81.3%)35/44(79.6%)17/20(85.0%)0.604
Parkinsonism(%)28/64(43.8%)19/44(43.2%)9/20(45.0%)0.623
Cognitive impairement(%)46/64(71.9%)34/44(77.3%)12/20(60.0%)0.154
  1. a Median (interquartile range)
  2. b Quantitative data is compared by Mann-Whitney U test and categorical data is compared by Fisher exact test between male and female patients