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Table 3 Hot cross bun (HCB) sign on MRI in MSA-C, SCA3, snd controls

From: Vertical pons hyperintensity and hot cross bun sign in cerebellar-type multiple system atrophy and spinocerebellar ataxia type 3

 Grade 1 or 2 HCB sign
(vertical or cruciform hyper-intensity)
Grade 2 HCB sign
(cruciform hyper-intensity)
MSA-C38/41 (92.7%)30/41 (73.2%)
SCA321/26 (80.8%)8/26 (30.8%)
Controls0/22 (0%)0/22 (0%)
P value for group comparison< 0.001a< 0.001a
p value for post-hoc group comparisons
 MSA-C vs. SCA30.141b0.001a
 MSA-C vs. Controls< 0.001a< 0.001a
 SCA3 vs. Controls< 0.001a0.004b
MSA-C within 2 years after onset22/24 (91.7%)13/24 (54.2%)
SCA3 within 2 years after onset2/4 (50.0%)0/4 (0%)
P value0.086b0.067b
MSA-C within 3 years after onset33/36 (91.7%)24/36 (66.7%)
SCA3 within 3 years after onset4/8 (50.0%)0/8 (0%)
P value0.014b0.001b
  1. aChi-squared test (post-hoc chi-squared tests adjusted for multiple comparison: P < 0.05/3 = 0.0167)
  2. bFisher's exact probability test (post-hoc Fisher's exact probability test adjusted for multiple comparison: P < 0.05/3 = 0.0167)