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Table 3 Hazard Ratios and 95% Confidence Intervals for Ischemic Stroke Subtypes by Low-grade Albuminuria Among HUNT 2 Participants, (n = 7261)

From: Low grade albuminuria as a risk factor for subtypes of stroke - the HUNT Study in Norway

  

Model 1

Model 2

ACR, mg/mmol

Cases/Person time in years

HR

95% CI

p for trend

HR

95% CI

p for trend

Lacunar stroke

  < 1

96/55733

1

(ref)

 

1

(ref)

 

 1 - < 2

38/16548

1.19

(0.82–1.74)

 

1.09

(0.75–1.6)

 

 2 - < 3

11/3786

1.45

(0.77–2.71)

 

1.25

(0.66–2.35)

 

  ≥ 3

28/6130

2.25

(1.48–3.45)

< 0.001

1.75

(1.12–2.72)

0.019

Cardio-embolic stroke

  < 1

56/55733

1

(ref)

 

1

(ref)

 

 1 - < 2

21/16548

0.98

(0.59–1.62)

 

0.96

(0.58–1.6)

 

 2 - < 3

7/3786

1.36

(0.62–2.98)

 

1.23

(0.56–2.73)

 

  ≥ 3

12/6130

1.43

(0.76–2.67)

0.242

1.22

(0.64–2.3)

0.518

Large artery atherosclerotic stroke

  < 1

45/55733

1

(ref)

 

1

(ref)

 

 1 - < 2

16/16548

1.03

(0.58–1.83)

 

0.98

(0.55–1.76)

 

 2 - < 3

7/3786

1.87

(0.84–4.16)

 

1.49

(0.66–3.35)

 

  ≥ 3

12/6130

2

(1.05–3.79)

0.022

1.51

(0.78–2.94)

0.186

Stroke of other determined etiology

  < 1

6/55733

1

(ref)

 

1

(ref)

 

 1 - < 2

2/16548

0.9

(0.22–5.52)

 

1

(0.19–5.13)

 

 2 - < 3

0/3786

      

  ≥ 3

2/6130

2.4

(0.58–14.64)

0.353

2.09

(0.37–11.72)

0.619

Stroke of undetermined etiology

  < 1

183/55733

1

(ref)

 

1

(ref)

 

 1 - < 2

85/16548

1.16

(0.9–1.51)

 

1.1

(0.85–1.43)

 

 2 - < 3

24/3786

1.38

(0.9–2.12)

 

1.24

(0.8–1.9)

 

  ≥ 3

52/6130

1.83

(1.34–2.49)

< 0.001

1.53

(1.11–2.11)

0.009

  1. ACR Urine albumin-creatinine ratio; CI Confidence interval; HR Hazard ratio
  2. Model 1 is age adjusted
  3. Model 2 is additionally adjusted for sex, smoking status, educational status, BMI, EGFR, DM, systolic blood pressure, non-HDL Cholesterol, Triglycerides