| Inclusion criteria |
Diagnosis | A definite diagnosis of PMS determined by neurologist |
Age | 25–65 years |
Ambulation | Not wheelchair dependent (EDSS,<  7.0) |
 | Exclusion criteria |
Substance abuse | Use of illicit drugs, PCP, LSD, Stimulants, Amphetamines, Barbiturates, etc. (Cannabis use is accepted). |
Neurological history | Relapses in the past 3 months, a history of central nervous system disease other than PMS such as stroke, Parkinson’s disease, traumatic brain injury, etc. |
Severe mental illness | Psychotic symptoms, Bipolar Disorder, Schizophrenia. |
Medications | Steroid use within the past 3 months. |
Transport | Unable or unwilling to travel to the center for testing and training or requiring transportation by ambulance. |
Medical contradiction | No medical clearance provided by a physician upon failure of AHA/ACSM Health/Fitness Facility Pre participation Screening Questionnaire. |
Current exercise activity | Currently performing enough physical activity for health benefits based a GLTEQ score > 23). |