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Table 3 Correlation between outcome measures taken at baseline

From: Longitudinal functional and imaging outcome measures in FKRP limb-girdle muscular dystrophy

Outcome DEXA – body fat DEXA – LBM MEP MIP FEV1 FVC MMT PUL TUG 4SC 10MWR 2MWD
MRI muscle fat fraction (MFF), % −0.027 −0.718 −0.535 − 0.448 − 0.572 − 0.605 − 0.759 − 0.267 0.565 0.700 0.733 − 0.794
0.9149 0.0008 0.0268 0.0711 0.0164 0.01 0.0003* 0.2834 0.0227 0.0026 0.0013 0.0001*
Two minute walk distance (2MWD), meters 0.071 0.765 0.587 0.481 0.514 0.608 0.838 0.316 −0.555 −0.671 −0.846 NA
0.7721 0.0001* 0.0105 0.0434 0.0290 0.0074 < 0.00001* 0.1873 0.0258 0.0044 0.0001*
Ten meter walk/run (10MWR), seconds −0.373 −0.855 − 0.641 − 0.465 −0.582 − 0.666 −0.783 − 0.103 0.549 0.805 NA  
0.1546 < 0.00001* 0.0074 0.0693 0.0180 0.0048 0.0003* 0.7031 0.0276 0.0002*
Four-stair climb (4SC), seconds −0.138 −0.655 −0.356 −0.077 − 0.409 −0.402 − 0.560 −0.100 0.680 NA   
0.6091 0.0059 0.1758 0.7780 0.1156 0.1229 0.0242 0.7129 0.0038
Timed up-and-go (TUG), seconds 0.248 −0.493 −0.145 −0.287 −0.536 − 0.469 −0.549 − 0.342 NA    
0.3544 0.0526 0.5915 0.2813 0.0323 0.0671 0.0276 0.1950
Performance of upper limb (PUL) −0.296 −0.082 0.054 0.134 0.327 0.303 0.388 NA     
0.2186 0.7391 0.8302 0.5959 0.1854 0.2219 0.1003
Manual muscle sum score (MMT) 0.205 0.792 0.816 0.757 0.665 0.721 NA      
0.3997 0.0001* < 0.00001* 0.0003* 0.0026 0.0007
Forced vital capacity (FVC), liters 0.017 0.667 0.625 0.696 0.956 NA       
0.946 0.0025 0.0073 0.0019 < 0.00001*
Forced expiratory volume (FEV1), liters −0.035 0.579 0.645 0.767 NA        
0.8917 0.0119 0.0052 0.0003*
Mean inspiratory pressure (MIP), cmH2O 0.162 0.642 0.928 NA         
0.5210 0.0041 < 0.00001*
Mean expiratory pressure (MEP), cmH2O 0.289 0.748 NA          
0.2456 0.0004*
DEXA - lean body mass (LBM), kg 0.374 NA           
0.1143
DEXA - body fat, kg NA            
  1. Pearson correlation coefficients (top) and p-values (bottom) are shown for the 2MWD, MMT, PFT, DEXA, and MRI data. Spearman correlation coefficients are shown for the FSC, TUG, and 10MWR due to non-normal distribution. Asterisks note statistically significant p-values under a Bonferroni adjustment