Longitudinal functional and imaging outcome measures in FKRP limb-girdle muscular dystrophy

Leung, Doris G.; Bocchieri, Alex E.; Ahlawat, Shivani; Jacobs, Michael A.; Parekh, Vishwa S.; Braverman, Vladimir; Summerton, Katherine; Mansour, Jennifer; Bibat, Genila; Morris, Carl; Marraffino, Shannon; Wagner, Kathryn R.

doi:10.1186/s12883-020-01774-5

BMC Neurology

Table 3 Correlation between outcome measures taken at baseline

From: Longitudinal functional and imaging outcome measures in FKRP limb-girdle muscular dystrophy

Outcome	DEXA – body fat	DEXA – LBM	MEP	MIP	FEV1	FVC	MMT	PUL	TUG	4SC	10MWR	2MWD
MRI muscle fat fraction (MFF), %	−0.027	−0.718	−0.535	− 0.448	− 0.572	− 0.605	− 0.759	− 0.267	0.565	0.700	0.733	− 0.794
MRI muscle fat fraction (MFF), %	0.9149	0.0008	0.0268	0.0711	0.0164	0.01	0.0003*	0.2834	0.0227	0.0026	0.0013	0.0001*
Two minute walk distance (2MWD), meters	0.071	0.765	0.587	0.481	0.514	0.608	0.838	0.316	−0.555	−0.671	−0.846	NA
Two minute walk distance (2MWD), meters	0.7721	0.0001*	0.0105	0.0434	0.0290	0.0074	< 0.00001*	0.1873	0.0258	0.0044	0.0001*	NA
Ten meter walk/run (10MWR), seconds	−0.373	−0.855	− 0.641	− 0.465	−0.582	− 0.666	−0.783	− 0.103	0.549	0.805	NA
Ten meter walk/run (10MWR), seconds	0.1546	< 0.00001*	0.0074	0.0693	0.0180	0.0048	0.0003*	0.7031	0.0276	0.0002*	NA
Four-stair climb (4SC), seconds	−0.138	−0.655	−0.356	−0.077	− 0.409	−0.402	− 0.560	−0.100	0.680	NA
Four-stair climb (4SC), seconds	0.6091	0.0059	0.1758	0.7780	0.1156	0.1229	0.0242	0.7129	0.0038	NA
Timed up-and-go (TUG), seconds	0.248	−0.493	−0.145	−0.287	−0.536	− 0.469	−0.549	− 0.342	NA
Timed up-and-go (TUG), seconds	0.3544	0.0526	0.5915	0.2813	0.0323	0.0671	0.0276	0.1950	NA
Performance of upper limb (PUL)	−0.296	−0.082	0.054	0.134	0.327	0.303	0.388	NA
Performance of upper limb (PUL)	0.2186	0.7391	0.8302	0.5959	0.1854	0.2219	0.1003	NA
Manual muscle sum score (MMT)	0.205	0.792	0.816	0.757	0.665	0.721	NA
Manual muscle sum score (MMT)	0.3997	0.0001*	< 0.00001*	0.0003*	0.0026	0.0007	NA
Forced vital capacity (FVC), liters	0.017	0.667	0.625	0.696	0.956	NA
Forced vital capacity (FVC), liters	0.946	0.0025	0.0073	0.0019	< 0.00001*	NA
Forced expiratory volume (FEV1), liters	−0.035	0.579	0.645	0.767	NA
Forced expiratory volume (FEV1), liters	0.8917	0.0119	0.0052	0.0003*	NA
Mean inspiratory pressure (MIP), cmH2O	0.162	0.642	0.928	NA
Mean inspiratory pressure (MIP), cmH2O	0.5210	0.0041	< 0.00001*	NA
Mean expiratory pressure (MEP), cmH2O	0.289	0.748	NA
Mean expiratory pressure (MEP), cmH2O	0.2456	0.0004*	NA
DEXA - lean body mass (LBM), kg	0.374	NA
DEXA - lean body mass (LBM), kg	0.1143	NA
DEXA - body fat, kg	NA

Pearson correlation coefficients (top) and p-values (bottom) are shown for the 2MWD, MMT, PFT, DEXA, and MRI data. Spearman correlation coefficients are shown for the FSC, TUG, and 10MWR due to non-normal distribution. Asterisks note statistically significant p-values under a Bonferroni adjustment

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