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Table 2 Multivariate logistic regression analyses to examine the effect of cytomegalovirus diseases on the development of moderate-to-severe dementia

From: Association between cytomegalovirus end-organ diseases and moderate-to-severe dementia: a population-based cohort study

Type of dementia CMV diseases Number of participants Events Total follow-up duration (person-years) IRa OR (95% CI)
Model 1 Model 2 Model 3
All No 3435 105 14,083 7.46 1 (Ref.) 1 (Ref.) 1 (Ref.)
Yes 687 38 2564 14.82 1.99 (1.37–2.88) 2.07 (1.42–3.03) 1.88 (1.23–2.82)
AD No 3435 77 14,083 5.47 1 (Ref.) 1 (Ref.) 1 (Ref.)
Yes 687 23 2564 8.97 1.65 (1.04–2.63) 1.69 (1.04–2.75) 1.62 (1.01–2.64)
VaD No 3435 12 14,083 0.85 1 (Ref.) 1 (Ref.) 1 (Ref.)
Yes 687 7 2564 2.73 3.14 (1.24–7.98) 3.30 (1.28–8.40) 2.87 (1.08–7.45)
Others No 3435 16 14,083 1.14 1 (Ref.) 1 (Ref.) 1 (Ref.)
Yes 687 8 2564 3.12 2.71 (1.16–6.34) 2.81 (1.89–6.65) 2.69 (1.07–6.43)
  1. Data are expressed as number or OR (95% CI). Events indicate the new-onset moderate-to-severe dementia. Model 1, non-adjusted; Model 2, age-, sex-, low income status, and BMI-adjusted; Model 3, age-, sex-, low income status-, BMI-, SOT recipients-, HSCT recipients-, malignant neoplasms-, ESRD on dialysis-, NIDDM-, hypertension-, and dyslipidaemia-adjusted
  2. Abbreviations: AD Alzheimer’s disease, BMI body mass index, CI confidence interval, CMV cytomegalovirus, ESRD end-stage renal disease, HSCT haematopoietic stem cell transplantation, IR incidence rate, NIDDM non-insulin-dependent diabetes mellitus, No., number of patients, OR odds ratio, Ref. reference, SOT solid organ transplantation, VaD vascular dementia
  3. aPer 1000 person-years