Association between cytomegalovirus end-organ diseases and moderate-to-severe dementia: a population-based cohort study

Table 2 Multivariate logistic regression analyses to examine the effect of cytomegalovirus diseases on the development of moderate-to-severe dementia

Type of dementia	CMV diseases	Number of participants	Events	Total follow-up duration (person-years)	IR^a	OR (95% CI)
Type of dementia	CMV diseases	Number of participants	Events	Total follow-up duration (person-years)	IR^a	Model 1	Model 2	Model 3
All	No	3435	105	14,083	7.46	1 (Ref.)	1 (Ref.)	1 (Ref.)
All	Yes	687	38	2564	14.82	1.99 (1.37–2.88)	2.07 (1.42–3.03)	1.88 (1.23–2.82)
AD	No	3435	77	14,083	5.47	1 (Ref.)	1 (Ref.)	1 (Ref.)
AD	Yes	687	23	2564	8.97	1.65 (1.04–2.63)	1.69 (1.04–2.75)	1.62 (1.01–2.64)
VaD	No	3435	12	14,083	0.85	1 (Ref.)	1 (Ref.)	1 (Ref.)
VaD	Yes	687	7	2564	2.73	3.14 (1.24–7.98)	3.30 (1.28–8.40)	2.87 (1.08–7.45)
Others	No	3435	16	14,083	1.14	1 (Ref.)	1 (Ref.)	1 (Ref.)
Others	Yes	687	8	2564	3.12	2.71 (1.16–6.34)	2.81 (1.89–6.65)	2.69 (1.07–6.43)

Data are expressed as number or OR (95% CI). Events indicate the new-onset moderate-to-severe dementia. Model 1, non-adjusted; Model 2, age-, sex-, low income status, and BMI-adjusted; Model 3, age-, sex-, low income status-, BMI-, SOT recipients-, HSCT recipients-, malignant neoplasms-, ESRD on dialysis-, NIDDM-, hypertension-, and dyslipidaemia-adjusted
Abbreviations: AD Alzheimer’s disease, BMI body mass index, CI confidence interval, CMV cytomegalovirus, ESRD end-stage renal disease, HSCT haematopoietic stem cell transplantation, IR incidence rate, NIDDM non-insulin-dependent diabetes mellitus, No., number of patients, OR odds ratio, Ref. reference, SOT solid organ transplantation, VaD vascular dementia
^aPer 1000 person-years

ISSN: 1471-2377