Table 2 Demographic and clinical characteristics of ischemic stroke patients with or without a TIA < 24 h stratified by rtPA. Results for continuous variables are presented as Mean ± SD, while discrete data are presented as percentage frequency. Pearson’s Chi-Square or Man Whitney U test is used to compare differences between demographic and clinical characteristics in rtPA treated groups
Demographic and clinical factors | Acute Ischemic Stroke with TIA < 24 h |  | Acute Ischemic Stroke without TIA < 24 h |  | ||
|---|---|---|---|---|---|---|
No rtPA Group | rtPA Group | No rtPA Group | rtPA Group | |||
Number of patients | 821 | 25 | P-value | 4142 | 1327 | P-Value |
Age Group: No. (%) | ||||||
  < 50 years | 89 (10.84) | 8 (32) | 0.004*a | 467 (11.3) | 191 (14.4) | 0.001*a |
 50–59 | 128 (15.59) | 3 (12) |  | 736 (17.8) | 260 (19.6) |  |
 60–69 | 197 (23.99) | 9 (36) |  | 981 (23.7) | 318 (24.0) |  |
 70–79 | 192 (23.38) | 3 (12) |  | 942 (22.7) | 289 (21.8) |  |
  > =80 | 215 (26.18) | 2 (8) |  | 1016 (24.5) | 269 (20.3) |  |
 Age Mean ± SD | 68.39 ± 14.33 | 57.8 ± 15.49 | < 0.001*b | 67.73 ± 14.69 | 65.76 ± 14.78 | < 0.001*b |
Race: No (%) | ||||||
 White | 675 (82.21) | 20 (80) | 0.878 | 3228 (77.9) | 1060 (79.9) | 0.313 |
 Black | 126 (15.34) | 4 (16) |  | 774 (18.7) | 228 (17.2) |  |
 Other | 20 (2.43) | 1 (4) |  | 140 (3.4) | 39 (2.9) |  |
Gender: No. (%) | ||||||
 Female | 437 (53.2) | 14 (56) | 0.784 | 2148 (51.9) | 659 (49.7) | 0.163 |
 Male | 384 (46.77) | 11 (44) |  | 1994 (48.1) | 668 (50.3) |  |
Medical History: No. (%) | ||||||
 Atrial Fib | 118 (14.4) | 0 (0) | 0.041*a | 713 (17.2) | 211 (15.9) | 0.266 |
 Coronary Artery Disease | 275 (33.49) | 8 (32) | 0.876 | 1262 (30.5) | 399 (30.1) | 0.782 |
 Carotid Artery Stenosis | 65 (7.91) | 2 (8) | 0.988 | 278 (6.7) | 56 (4.2) | 0.001*a |
 Depression | 119 (14.49) | 6 (24) | 0.187 | 516 (12.5) | 205 (15.4) | 0.005*a |
 Diabetes | 310 (37.75) | 10 (40) | 0.820 | 1520 (36.7) | 415 (31.3) | < 0.001*a |
 Drugs or Alcohol | 28 (3.41) | 3 (12) | 0.024*a | 260 (6.3) | 77 (5.8) | 0.532 |
 Dyslipidemia | 477 (58.09) | 15 (60) | 0.850 | 2055 (49.6) | 700 (52.8) | 0.047*a |
 Stroke Family History | 82 (9.98) | 5 (20) | 0.104 | 364 (8.8) | 130 (9.8) | 0.265 |
 Heart Failure | 83 (10.1) | 2 (8) | 0.730 | 453 (10.9) | 137 (10.3) | 0.531 |
 Hormonal Replacement Therapy | 11 (1.33) | 0 (0) | 0.560 | 48 (1.2) | 31 (2.3) | 0.002*a |
 Hypertension | 654 (79.65) | 21 (84) | 0.594 | 3262 (78.8) | 1044 (78.7) | 0.950 |
 Migraine | 23 (2.8) | 4 (16) | 0.001*a | 89 (2.1) | 45 (3.4) | 0.011*a |
 Obesity | 339 (41.29) | 17 (68) | 0.008*a | 1633 (39.4) | 678 (51.1) | < 0.001*a |
 Previous Stroke | 265 (32.27) | 9 (36) | 0.695 | 1134 (27.4) | 290 (21.9) | < 0.001*a |
 Previous TIA | 135 (16.44) | 5 (20) | 0.637 | 334 (8.1) | 143 (10.8) | 0.002*a |
 Prosthetic Heart Valve | 11 (1.33) | 0 (0) | 0.560 | 52 (1.3) | 10 (0.8) | 0.133 |
 Peripheral Vascular Disease | 83 (10.1) | 1 (4) | 0.314 | 321 (7.7) | 79 (6.0) | 0.029*a |
 Chronic Renal Disease | 66 (8.03) | 0 (0) | 0.140 | 368 (8.9) | 79 (6.0) | 0.001*a |
 Sickle Cell | 1 (0.12) | 0 (0) | 0.861 | 4 (0.1) | 0 (0) | 0.257 |
 Sleep Apnea | 32 (3.89) | 2 (8) | 0.304 | 125 (3.0) | 45 (3.4) | 0.495 |
 Smoker | 169 (20.58) | 5 (20) | 0.943 | 1098 (26.5) | 388 (29.2) | 0.052 |
Medication History: No (%) | ||||||
 HTN medication | 169 (20.58) | 5 (20) | 0.828 | 2851 (68.8) | 943 (71.1) | 0.125 |
 Cholesterol Reducer | 440 (53.59) | 16 (64) | 0.304 | 1796 (43.4) | 632 (47.6) | 0.006*a |
 Diabetes medication | 260 (31.66) | 9 (36) | 0.647 | 1164 (28.1) | 331 (24.9) | 0.025*a |
 Antidepressant | 126 (15.34) | 5 (20) | 0.526 | 489 (11.8) | 222 (16.7) | < 0.001*a |
Initial NIHSS Score: No (%) | ||||||
 0–9 | 658 (91.13) | 19 (76) | 0.001*a | 2556 (76.3) | 773 (59.4) | < 0.001*a |
 10–14 | 50 (6.92) | 3 (12) |  | 308 (9.2) | 199 (16.1) |  |
 15–20 | 9 (1.24) | 3 (12) |  | 308 (9.2) | 193 (15.6) |  |
 21–25 | 5 (0.69) | 0 (0) |  | 180 (5.4) | 110 (8.9) |  |
 NIHSS Score Mean ± SD | 3.36 ± 4.02 | 6.16 ± 5.46 | 0.018*b | 7.43 ± 8.11 | 10.55 ± 8.18 | < 0.001*b |
Lab values: Mean ± SD | ||||||
 Total cholesterol (mg/dl) | 168.15 ± 43.98 | 159.45 ± 44.73 | 0.341 | 173.01 ± 53.6 | 168.66 ± 46.48 | 0.006*b |
 Triglycerides (mg/dl) | 146.1 ± 94.44 | 154.79 ± 78.82 | 0.656 | 139.25 ± 104.13 | 140.71 ± 107.94 | 0.674 |
 HDL (mg/dl) | 42.78 ± 14.33 | 43.58 ± 12.75 | 0.787 | 41.77 ± 13.91 | 41.8 ± 13.65 | 0.946 |
 LDL (mg/dl) | 98.46 ± 36.6 | 90.79 ± 35.42 | 0.312 | 105.39 ± 42.06 | 102.52 ± 39.07 | 0.029*b |
 Lipids (mg/dl) | 7.4 ± 26.61 | 6.55 ± 2 | 0.881 | 6.64 ± 2.83 | 6.25 ± 1.6 | < 0.001*b |
 Blood Glucose | 138.17 ± 76.44 | 152.16 ± 91.72 | 0.371 | 149.22 ± 82.86 | 141.29 ± 74.84 | 0.001*b |
 Serum Creatinine (mg/dl | 1.45 ± 3.5 | 1.02 ± 0.37 | 0.547 | 1.34 ± 1.27 | 1.14 ± 0.75 | < 0.001*b |
 INR | 1.19 ± 0.5 | 0.98 ± 0.06 | < 0.001*b | 1.17 ± 0.57 | 1.06 ± 0.15 |  |
Vital Signs: Mean ± SD | ||||||
 Heart Rate | 77.97 ± 14.83 | 79.6 ± 15.71 | 0.590 | 82.07 ± 18.94 | 81.81 ± 17.18 | 0.644 |
 Blood Pressure Systolic (mmHg) | 148.76 ± 27.95 | 143.6 ± 25.05 | 0.362 | 151.99 ± 30.04 | 151.31 ± 26.92 | 0.439 |
 Blood Pressure Diastolic (mmHg) | 79.24 ± 17.48 | 83.4 ± 18.56 | 0.243 | 82.29 ± 19.38 | 82.92 ± 18.3 | 0.277 |