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Table 2 Demographic and clinical characteristics of ischemic stroke patients with or without a TIA < 24 h stratified by rtPA. Results for continuous variables are presented as Mean ± SD, while discrete data are presented as percentage frequency. Pearson’s Chi-Square or Man Whitney U test is used to compare differences between demographic and clinical characteristics in rtPA treated groups

From: Ischemic stroke with a preceding Trans ischemic attack (TIA) less than 24 hours and thrombolytic therapy

Demographic and clinical factors Acute Ischemic Stroke with TIA < 24 h   Acute Ischemic Stroke without TIA < 24 h  
No rtPA Group rtPA Group No rtPA Group rtPA Group
Number of patients 821 25 P-value 4142 1327 P-Value
Age Group: No. (%)
  < 50 years 89 (10.84) 8 (32) 0.004*a 467 (11.3) 191 (14.4) 0.001*a
 50–59 128 (15.59) 3 (12)   736 (17.8) 260 (19.6)  
 60–69 197 (23.99) 9 (36)   981 (23.7) 318 (24.0)  
 70–79 192 (23.38) 3 (12)   942 (22.7) 289 (21.8)  
  > =80 215 (26.18) 2 (8)   1016 (24.5) 269 (20.3)  
 Age Mean ± SD 68.39 ± 14.33 57.8 ± 15.49 < 0.001*b 67.73 ± 14.69 65.76 ± 14.78 < 0.001*b
Race: No (%)
 White 675 (82.21) 20 (80) 0.878 3228 (77.9) 1060 (79.9) 0.313
 Black 126 (15.34) 4 (16)   774 (18.7) 228 (17.2)  
 Other 20 (2.43) 1 (4)   140 (3.4) 39 (2.9)  
Gender: No. (%)
 Female 437 (53.2) 14 (56) 0.784 2148 (51.9) 659 (49.7) 0.163
 Male 384 (46.77) 11 (44)   1994 (48.1) 668 (50.3)  
Medical History: No. (%)
 Atrial Fib 118 (14.4) 0 (0) 0.041*a 713 (17.2) 211 (15.9) 0.266
 Coronary Artery Disease 275 (33.49) 8 (32) 0.876 1262 (30.5) 399 (30.1) 0.782
 Carotid Artery Stenosis 65 (7.91) 2 (8) 0.988 278 (6.7) 56 (4.2) 0.001*a
 Depression 119 (14.49) 6 (24) 0.187 516 (12.5) 205 (15.4) 0.005*a
 Diabetes 310 (37.75) 10 (40) 0.820 1520 (36.7) 415 (31.3) < 0.001*a
 Drugs or Alcohol 28 (3.41) 3 (12) 0.024*a 260 (6.3) 77 (5.8) 0.532
 Dyslipidemia 477 (58.09) 15 (60) 0.850 2055 (49.6) 700 (52.8) 0.047*a
 Stroke Family History 82 (9.98) 5 (20) 0.104 364 (8.8) 130 (9.8) 0.265
 Heart Failure 83 (10.1) 2 (8) 0.730 453 (10.9) 137 (10.3) 0.531
 Hormonal Replacement Therapy 11 (1.33) 0 (0) 0.560 48 (1.2) 31 (2.3) 0.002*a
 Hypertension 654 (79.65) 21 (84) 0.594 3262 (78.8) 1044 (78.7) 0.950
 Migraine 23 (2.8) 4 (16) 0.001*a 89 (2.1) 45 (3.4) 0.011*a
 Obesity 339 (41.29) 17 (68) 0.008*a 1633 (39.4) 678 (51.1) < 0.001*a
 Previous Stroke 265 (32.27) 9 (36) 0.695 1134 (27.4) 290 (21.9) < 0.001*a
 Previous TIA 135 (16.44) 5 (20) 0.637 334 (8.1) 143 (10.8) 0.002*a
 Prosthetic Heart Valve 11 (1.33) 0 (0) 0.560 52 (1.3) 10 (0.8) 0.133
 Peripheral Vascular Disease 83 (10.1) 1 (4) 0.314 321 (7.7) 79 (6.0) 0.029*a
 Chronic Renal Disease 66 (8.03) 0 (0) 0.140 368 (8.9) 79 (6.0) 0.001*a
 Sickle Cell 1 (0.12) 0 (0) 0.861 4 (0.1) 0 (0) 0.257
 Sleep Apnea 32 (3.89) 2 (8) 0.304 125 (3.0) 45 (3.4) 0.495
 Smoker 169 (20.58) 5 (20) 0.943 1098 (26.5) 388 (29.2) 0.052
Medication History: No (%)
 HTN medication 169 (20.58) 5 (20) 0.828 2851 (68.8) 943 (71.1) 0.125
 Cholesterol Reducer 440 (53.59) 16 (64) 0.304 1796 (43.4) 632 (47.6) 0.006*a
 Diabetes medication 260 (31.66) 9 (36) 0.647 1164 (28.1) 331 (24.9) 0.025*a
 Antidepressant 126 (15.34) 5 (20) 0.526 489 (11.8) 222 (16.7) < 0.001*a
Initial NIHSS Score: No (%)
 0–9 658 (91.13) 19 (76) 0.001*a 2556 (76.3) 773 (59.4) < 0.001*a
 10–14 50 (6.92) 3 (12)   308 (9.2) 199 (16.1)  
 15–20 9 (1.24) 3 (12)   308 (9.2) 193 (15.6)  
 21–25 5 (0.69) 0 (0)   180 (5.4) 110 (8.9)  
 NIHSS Score Mean ± SD 3.36 ± 4.02 6.16 ± 5.46 0.018*b 7.43 ± 8.11 10.55 ± 8.18 < 0.001*b
Lab values: Mean ± SD
 Total cholesterol (mg/dl) 168.15 ± 43.98 159.45 ± 44.73 0.341 173.01 ± 53.6 168.66 ± 46.48 0.006*b
 Triglycerides (mg/dl) 146.1 ± 94.44 154.79 ± 78.82 0.656 139.25 ± 104.13 140.71 ± 107.94 0.674
 HDL (mg/dl) 42.78 ± 14.33 43.58 ± 12.75 0.787 41.77 ± 13.91 41.8 ± 13.65 0.946
 LDL (mg/dl) 98.46 ± 36.6 90.79 ± 35.42 0.312 105.39 ± 42.06 102.52 ± 39.07 0.029*b
 Lipids (mg/dl) 7.4 ± 26.61 6.55 ± 2 0.881 6.64 ± 2.83 6.25 ± 1.6 < 0.001*b
 Blood Glucose 138.17 ± 76.44 152.16 ± 91.72 0.371 149.22 ± 82.86 141.29 ± 74.84 0.001*b
 Serum Creatinine (mg/dl 1.45 ± 3.5 1.02 ± 0.37 0.547 1.34 ± 1.27 1.14 ± 0.75 < 0.001*b
 INR 1.19 ± 0.5 0.98 ± 0.06 < 0.001*b 1.17 ± 0.57 1.06 ± 0.15  
Vital Signs: Mean ± SD
 Heart Rate 77.97 ± 14.83 79.6 ± 15.71 0.590 82.07 ± 18.94 81.81 ± 17.18 0.644
 Blood Pressure Systolic (mmHg) 148.76 ± 27.95 143.6 ± 25.05 0.362 151.99 ± 30.04 151.31 ± 26.92 0.439
 Blood Pressure Diastolic (mmHg) 79.24 ± 17.48 83.4 ± 18.56 0.243 82.29 ± 19.38 82.92 ± 18.3 0.277
  1. Notes:
  2. aPearson’s Chi-Squared test
  3. bStudent’s T test
  4. * P-value < 0.05