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Table 2 Summary of Case Reports of isolated Zic4-Antibodies

From: Rhombencephalitis associated with isolated Zic4-antibodies in Paraneoplastic cerebellar degeneration: a case report

AuthorAge/SexAssociated TumorPrimary syndrome at DiagnosisSymptomsTreatmentTreatment response
Current Study67/FSCLCBrainstem, PCDOpsoclonus-Myoclonus Syndrome, DysautonomiaMethylprednisolone, Plasmapheresis, IVIG, Lobectomy, Cyclophosphamidenone
Salazar et al. 2018 [9]70/MNone, sCJDBrainstem, PCDDementia, Ataxia, Myoclonus, DysautonomiaMethylprednisolonenone
Eye et al. 2018 [10]94/FDLBCL,
SMM
PCDDownbeat Nystagmus, alternating Skew Deviation, Gait AtaxiaChemotherapy,
Rituximab
Improvement but persisting symptoms
Aydin et al. 2018 [11]40/FDuctal breast cancerSSNPain, Asymmetric Numbnessn/aImprovement but persisting symptoms
Kerasnoudis et al. 2011 [12]60/FOvarian adenocarcinomaPCDProgressive Gait Ataxia, DysarthriaMethylprednisolone,
Ovariectomy, Chemotherapy
Complete clinical remission
Sabater et al. 2008 [8]n/aSCLCPCDn/an/an/a
Bataller et al. 2004 [6]67a/
8: M, 1: F
8: SCLC
1: no tumor
7: PCD
1: PCD + LE
1: LEMS
Cerebellar Ataxia
Cerebellar Ataxia, Cognitive Dysfunction
Myasthenia
n/an/a
  1. amedian age