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Table 1 Baseline characteristics during the first 24 h in the NICU

From: Thrombocytopenia and platelet course on hospital mortality in neurological intensive care unit: a retrospective observational study from large database

 TP – TP
(N = 817)
TP – NTP
(N = 666)
NTP – TP
(N = 980)
NTP – NTP
(N = 4, 987)
P value
Age, years (median, [IQR])67 (56, 78)65 (52, 76)64 (51, 75)63 (50, 75)< 0.001
Gender: male (n (%))537 (66)401 (60)544 (56)2467 (49)< 0.001
BMI (median, [IQR])26.6 (23.2, 31.4)27.4 (23.4, 32)27.4 (23.6, 32.3)27.5 (23.5, 32.4)0.019
Ethnicity (n (%))0.504
 Caucasian621 (76)498 (75)720 (73)3669 (74) 
 African American108 (13)98 (15)143 (15)731 (15) 
 Hispanic32 (4)21 (3)41 (4)192 (4) 
 Asian15 (2)12 (2)15 (2)74 (1) 
 Native American10 (1)2 (0)4 (0)38 (1) 
 Other/Unknown31 (4)35 (5)57 (6)283 (6) 
Comorbidities (n (%)) 
 Hypertension401 (49)322 (48)484 (49)2422 (49)0.96
 Diabetes mellitus190 (23)130 (20)222 (23)1131 (23)0.288
 Respiratory disease87 (11)65 (10)74 (8)465 (9)0.139
 Heart failure105 (13)76 (11)90 (9)342 (7)< 0.001
 Cirrhosis82 (10)18 (3)17 (2)31 (1)< 0.001
 Chronic renal insufficiency116 (14)66 (10)96 (10)295 (6)< 0.001
 Cancer208 (25)103 (15)145 (15)633 (13)< 0.001
Disease category (n (%))< 0.001
 Postoperation162 (20)169 (25)234 (24)1128 (23) 
 Ischemic stroke97 (12)82 (12)121 (12)964 (19) 
 Traumatic brain injury75 (9)62 (9)94 (10)341 (7) 
 Intracranial hemorrhage65 (8)51 (8)97 (10)551 (11) 
 Hematoma subdural54 (7)32 (5)42 (4)234 (5) 
 Epilepsy42 (5)35 (5)41 (4)216 (4) 
 Multiple Trauma37 (5)38 (6)59 (6)137 (3) 
 Subarachnoid hemorrhage15 (2)12 (2)26 (3)185 (4) 
 Neoplasm19 (2)6 (1)26 (3)215 (4) 
 Others251 (31)179 (27)240 (24)1016 (20) 
Vital signs, (median, [IQR])
 Maximum Temperature, °C37.2 (36.9, 37.7)37.3 (37, 37.9)37.4 (37, 37.9)37.2 (36.9, 37.6)< 0.001
 Minimum Temperature, °C36.4 (36.1, 36.6)36.5 (36.1, 36.7)36.4 (36.1, 36.7)36.5 (36.2, 36.7)< 0.001
 Maximum HR, beats/min98 (86, 113)103 (89, 119)104 (90, 120)99 (87, 112)< 0.001
 Minimum HR, beats/min66 (58, 77)67 (59, 79)68 (59, 79)65 (58, 75)< 0.001
 Maximum RR26 (23, 30)26 (23, 31)26 (23, 31)26 (23, 30)0.034
 Minimum RR12 (10, 14)12 (10, 14)12 (10, 14)12 (10, 14)0.076
 Maximum MBP, mmHg104 (95, 117)105 (95, 119)106 (96, 120)107 (97, 121)< 0.001
 Minimum MBP, mmHg64 (55, 73)64 (56, 73)64 (56, 72)67 (59, 76)< 0.001
Laboratory test, (median, [IQR])
 Maximum hemoglobin, g/dl12.2 (10.5, 13.8)12.5 (11.1, 14)13 (11.3, 14.5)12.9 (11.4, 14.2)< 0.001
 Minimum hemoglobin, g/dl10.84 (8.5, 12.5)10.9 (9.1, 12.5)11.4 (9.5, 13.1)11.9 (10.3, 13.2)< 0.001
 Maximum WBC, × 109/L8.9 (6.3, 13.1)10.8 (7.9,14.3)12.9 (9.7, 16.8)11.89 (9, 15.4)< 0.001
 Minimum WBC, × 109/L6.6 (4.7, 9.3)8 (6, 10.1)9.5 (7.1, 12.7)9.4 (7.4, 12.2)< 0.001
Disease severity, (median, [IQR])
 APACHE IV score53 (41, 71)52 (39, 68)55 (38, 72)44 (33, 59)< 0.001
 GCS14 (10, 15)14 (9, 15)13 (8, 15)14 (11, 15)< 0.001
  1. Data are median (interquartile range) or No / Total (%)
  2. NICU Neurological intensive care unit, TP Thrombocytopenia, NTP Non thrombocytopenia, IQR Interquartile range, BMI Body mass index, HR Heart rate, RR Respiratory rate, MAP Mean arterial pressure, WBC White blood cell, APACHE Acute Physiology and Chronic Health Evaluation, GCS Glasgow coma scale