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Table 1 Baseline characteristics of 94 patients for the efficacy analyses

From: DL-3-n-butylphthalide improves cerebral hypoperfusion in patients with large cerebral atherosclerotic stenosis: a single-center, randomized, double-blind, placebo-controlled study

CharacteristicsNBP group(n = 48)Placebo group(n = 46)P values
Age (years)56.6 ± 11.560.6 ± 10.30.085
Gender (male)39 (81.2%)32 (69.6%)0.188
Hypertention (yes)38 (79.2%)39 (84.8%)0.479
Diabetes mellitus (yes)19 (39.6%)22 (47.8%)0.420
Hyperlipemia (yes)37 (77.1%)38 (82.6%)0.505
Coronary disease (yes)8 (16.7%)12 (26.1%)0.265
Smoking (yes)29 (60.4%)24 (52.2%)0.420
Previous TIA/ ischemic stroke
 Previous TIA8 (16.7%)9 (19.6%)0.600
 Previous ischemic stroke24 (50.0%)26 (56.5)
 None16 (33.3%)11 (23.9%)
Methods for assessing stenosis
 MRA35 (72.9%)30 (65.2%)0.316
 CTA1 (2.1%)0 (0%)
 DSA12 (25.0%)16 (34.8%)
Unilateral or bilateral
 Right side20 (41.7%)22 (47.8%)0.526
 Left side22 (45.8%)16 (34.8%)
 Bilateral6 (12.5%)8 (17.4%)
Stenotic location
 Extracranial ICA10 (20.8%)8 (17.4%)0.118
 Intracranial ICA23 (47.9%)31 (67.4%)
 MCA(M1 segment)15 (31.2%)7 (15.2%)
Carotid stenotic degree
 Severe stenosis(70–99%)35 (72.9%)40 (87.0%)0.090
 Occlusion13 (27.1%)6 (13.0%)
Integrity of CoW
 Integrity11 (22.9%)17 (37.0%)0.137
 Un-integrity37 (77.1%)29 (63.0%)
Time of follow-up (months)3.7 ± 1.63.5 ± 0.90.516
Discontinuation of OMT (yes)5 (10.4%)3 (6.5%)0.759
  1. NBP Dl-3-butylphthalide, TIA transient ischemic attack, MRA magnetic resonance angiography, CTA computed tomography angiography, DSA digital subtraction angiography, ICA internal carotid artery, MCA middle cerebral artery, CoW circle of Willis, OMT optimized medical therapy