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Table 2 Distribution of genotype and allele frequencies among MS patients and controls

From: Matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of multiple sclerosis: systematic review and meta-analysis

Study author

MS cases

Healthy control

P-HWE

MAF

CC

CT

TT

C

T

CC

CT

TT

C

T

MMP9

 Nelissen et al.

143

51

5

337

61

102

40

4

244

48

0/973

0/164

 Zivkovic et al.

146

41

0

333

41

200

74

8

474

90

0/716

0/16

 Benesova et al.

191

50

3

432

56

87

42

3

216

48

0/424

0/182

 Mirowska-Guzel et al.

128

103

3

359

109

136

50

4

322

58

0/811

0/153

 Fernandes et al.

117

35

6

269

47

156

32

3

344

38

0/369

0/099

 La Russa et al.

164

73

6

401

85

147

25

1

319

27

0/954

0/078

 Valado et al.

130

35

4

295

43

145

34

4

324

42

0/247

0/115

 Ibrahim et al.

28

21

1

77

23

78

21

1

177

23

0/751

0/115

 Sabbagh et al.

11

35

54

57

143

42

42

21

126

84

0/087

0/4

 Sadr et al.

96

60

14

252

88

163

33

4

359

41

0/144

0/103

MMP2

 Benesova et al.

143

84

13

370

110

75

40

17

190

74

0.004

0.28

 Aksoy et al.

40

56

6

136

68

77

25

0

179

25

0.15

0.123

 Liutkeviciene et al.

19

7

0

45

7

190

108

20

488

148

0.38

0.233

Study author

MS cases

Healthy control

P-HWE

MAF

5A/5A

5A/6A

6A/6A

5A

6A

5A/5A

5A/6A

6A/6A

5A

6A

MMP3

 Djuric et al.

24

102

58

150

218

37

130

69

204

268

0.06

0.568

 Rahimi et al.

3

66

52

72

170

1

67

38

69

143

0.006

0.675

  1. P-HWE, p-value for Hardy–Weinberg equilibrium; MAF Minor allele frequency of control group