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Table 1 Baseline Characteristics of Patients in the Derivation Cohort (n = 250)

From: Early prediction of cerebral-cardiac syndrome after ischemic stroke: the PANSCAN scale

Characteristics   no CCS, n = 112 CCS, n = 138 P-value
Age, n (%) < 65 76 (67.9) 50 (36.2) < 0.001*
≥65 36 (32.1) 88 (63.8)  
Sex, n (%) Male 70 (62.5) 56 (40.6) 0.001*
Female 42 (37.5) 82 (59.4)  
Stroke location, n (%) Brain stem 18 (16.1) 30 (21.7) 0.155
Others 94 (83.9) 98 (71.0)  
Temperature(°C), n (%) <37.5 98 (87.5) 118 (85.5) 0.713
≥37.5 14 (12.5) 20 (14.5)  
Mean Arterial Pressure (mmHg), n (%) Normal(<105) 44 (39.3) 60 (43.5) 0.521
Elevated(≥105) 68 (60.7) 78 (56.5)  
GCS Score, n (%) Conscious(15) 108 (96.4) 120 (87.0) 0.027*
Mild(12 ~ 14) 2 (1.8) 12 (8.7)  
Moderate(9 ~ 11) 0 (0.0) 4 (2.9)  
Coma(≤8) 2 (1.8) 2 (1.4)  
NIHSS Score, n (%) 0 54 (48.2) 20 (14.5) < 0.001*
1 ~ 4 44 (39.3) 60 (43.5)  
> 4 14 (12.5) 58 (42.0)  
Hypertension, n (%) No 32 (28.6) 58 (42.0) 0.34
Yes 80 (71.4) 80 (58.0)  
Diabetes, n (%) No 82 (74.5) 96 (70.6) 0.567
Yes 28 (25.5) 40 (29.4)  
Stroke Times, n (%) 1 times 96 (85.7) 110 (79.7) 0.245
> 1 times 16 (14.3) 28 (20.3)  
Smoking history, n (%) No 104 (92.9) 122 (88.4) 0.284
Yes 8 (7.1) 16 (11.6)  
Drinking history, n (%) No 72 (64.3) 98 (71.0) 0.277
Yes 40 (35.7) 40 (29.0)  
WBC(10^9/L), median (IQR)   6.30 (5.60, 8.18) 6.75 (5.43, 8.90) 0.497
Neutrophil(%), median (IQR)   61.3 (56.1, 66.1) 66.0 (59.6, 76.0) < 0.01*
PT(s), median (IQR)   13.0 (12.3, 13.9) 13.6 (12.8, 15.1) 0.012*
APTT(s), median (IQR)   36.6 (34.4, 38.3) 37.2 (34.4, 42.0) 0.031*
Fibrinogen(g/L), median (IQR)   3.29 (2.80, 3.83) 2.96 (2.51, 3.80) 0.022*
D-Dimer(< 500 μg/l FEU), median (IQR)   390.0 (300.0, 630.0) 490.0 (300.0, 1130.0) 0.023*
GPT(U/L), median (IQR)   18.0 (13.0,29.0) 17.0 (13.0,27.0) 0.609
GOT(U/L), median (IQR)   22.0 (19.0,27..8) 23.0 (18.0,28.5) 0.813
Serum Potassium, median (mmol/l)(IQR)   3.72 (3.48,3.89) 3.79 (3.37,3.95) 0.997
Blood Glucose, median (mmol/l) (IQR)   5.22 (4.75,6.41) 5.21 (4.66,7.27) 0.760
BUN (mmol/l), median (IQR)   4.59 (3.67,5.61) 5.00 (4.15,6.14) 0.037*
Serum creatinine (mmol/l),median (IQR)   58.0 (49.3,70.8) 59.0 (47.8,71.5) 0.784
Triglycerides (mmol/l), median (IQR)   1.31 (0.98,1.69) 1.20 (0.87,1.57) 0.098
LDL (mmol/l), median (IQR)   2.28 (1.77,2.97) 2.10 (1.48,2.55) 0.010
IMT, n (%) Normal 35 (34.7) 42 (34.1) 0.483
Thicken 66 (65.3) 81 (65.9)  
Carotid Stenosis, n (%) Normal 56 (55.4) 42 (33.6) < 0.001*
Mild 36 (35.7) 47 (37.6)  
Moderate to Severe 9 (8.9) 36 (28.8)  
LVEF(%), n (%) < 50 2 (2.2) 6 (5.0) 0.014*
50 ~ 55 0 (0.0) 3 (2.5)  
55 ~ 60 14 (15.1) 27 (22.3)  
≥60 77 (82.8) 85 (70.2)  
  1. *indicated P < 0.05
  2. Abbreviations: GCS Glasgow coma scale, NIHSS National Institutes of Health Stroke Scale, WBC White blood cell, GPT Glutamic Pyruvic Transaminase, GOT Glutamic-Oxalacetic Transaminease, BUN Blood Urea Nitrogen, LDL Low Density Lipoprotein, IMT Intima-Media Thickness, LVEF Left Ventricular Ejection Fraction, IQR interquartile range, FEU Fibrinogen Equivalent Units