Table 2 Summary of included studies
Author; Year | Sample size (control/treated) | Gender; Strain; Species; weight | Duration of occlusion (minute) | Model | Stroke to treatment interval (hours) | Type of administration | Type of graft | Number of transplanted cells | Outcome | Follow up duration (day) |
|---|---|---|---|---|---|---|---|---|---|---|
Chen; 2016 [41] | 12 / 12 | Male; Sprague-Dawley; Rat; 350–375 g | 50 | MCAO | 3 | IV | Xenograft | 1.2 × 106 | Neuorologic | 28 |
Chi; 2016 [42] | 3 / 3 | NR; BALB/c; Mice; 25 g | Permanent | MCAO with thrombin | 2 | IC | Xenograft | 1 × 106 | Motor | 14 |
Chung; 2015 [43] | 5 / 5 | Male; Sprague-Dawley; Rat; 250–300 g | 7 | Carotid clamp | 0 | IV | Xenograft | 1 × 106 | Motor | 7 |
Chung; 2017 [44] | 8 / 8 | Male; Sprague-Dawley; Rat; 250–300 g | 7 | Carotid clamp | 0 | IV | Xenograft | 1 × 106 | Motor | 7 |
Du; 2014 [45] | 20 / 60 | Male; Sprague-Dawley; Rat; 260–280 g | 90 | Carotid clamp | 24 | IC/IA/IV | Allograft | 5 × 105 | Neuorologic | 21 |
Ghazavi; 2017 [46] | 16 / 8 | Male; Wistar; Rat; 220–270 g | 30 | MCAO | 0.5 | IV | Allograft | 2 × 106 | Motor | 1 |
Gutiérrez-Fernández; 2013 [47] | 10 / 10 | Male; Sprague-Dawley; Rat; 250–300 g | Permanent | MCAO | 0.5 | IV | Allograft | 2 × 106 | Motor | 14 |
Gutiérrez-Fernández; 2015 [48] | 15 / 30 | Male; Sprague-Dawley; Rat; 250–320 g | Permanent | MCAO | 0.5 | IV | Xenograft/Allograft | 2 × 106 | Motor | 14 |
Ikegame; 2011 [49] | 9 / 10 | Male; C57BL/6 J; Mice; NR | 90 | MCAO | 0 | IV | Allograft | 2 × 105 | Neuorologic | 1 |
Jiang; 2014 [50] | 20 / 20 | Male; Sprague-Dawley; Rat; 300–350 g | 90 | MCAO | 0 | IA | Autograft | 2 × 106 | Neuorologic | 28 |
Kim; 2006 | 9 / 15 | Male; Sprague-Dawley; Rat; 250–300 g | Permanent | MCAO | 336 | IV / IC | Autograft | 1 × 106 | Motor | 70 |
Leu; 2010 [52] | 15 / 15 | Male; Sprague-Dawley; Rat; 300–350 g | 180 | MCAO | 24 | IV | Allograft | 2 × 106 | Neuorologic | 21 |
Li; 2016 [53] | 6 / 6 | Male; Sprague-Dawley; Rat; NR | Permanent | MCAO | 24 | IV | Autograft | 5 × 105 | Neuorologic | 28 |
Liu; 2014 [54] | 24 / 24 | Male; Sprague-Dawley; Rat; 200–250 g | 60 | MCAO | 24 | IC | Xenograft | 5 × 105 | Neuorologic | 28 |
Oh; 2015 [55] | 31 / 39 | Male; Sprague-Dawley; Rat; 280 to 300 g | 90 | MCAO | 24 | IA | Xenograft | 5 × 105 | Motor/Neuorologic | 56 |
Seo; 2013 [56] | 17 / 19 | Male/female; CD-1; Mice; NR | 90 | Carotid clamp | 1008 | IC | Xenograft | 1 × 105 | Motor | 56 |
Yang; 2011 [57] | 12 / 12 | Male; Sprague-Dawley; Rat; NR | 60 | MCAO | 0 | IV | Allograft | 1 × 107 | Motor | 28 |
Yin; 2015 [58] | 10 / 10 | Male; Sprague-Dawley; Rat; 250–300 | 90 | MCAO | 0 | IC | Xenograft | 1 × 104 | Neuorologic | 28 |
Zhao; 2017 [59] | 8 / 8 | Male; Sprague-Dawley; Rat; 250–320 | 120 | MCAO | 0 | IV | Allograft | 1 × 106 | Neuorologic/Motor | 28 |
Zhou; 2015 [60] | 7 / 7 | Male; C57/BL6; Mice; NR | 90 | MCAO | 168 | IC | Xenograft | 5 × 106 | Motor | 49 |