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Table 1 Features of ever reported restless abdomen cases

From: Restless abdomen: a spectrum or a phenotype variant of restless legs syndrome?

  Age & Gender Medical history Duration of symptoms, y Main clinical manifestations Diagnostic criteria Supportive criteria Nature of the disease
D1 D2 D3 D4 D5 S1 S2 S3 S4 S5
2003 Italy 72 M Facial tics since adolescence 4 An unpleasant restless sensation originating in his lower abdomen, spreading then to the lower limbs and associated with a compelling need to move the legs. Y Y Y Y Y Y Y N / / Part of the phenotypic spectrum of RLS
2011 Spain 62 M / 14 Nocturnal awakenings due to a “nervous twitchy feeling” in his abdomen. Y Y Y Y Y N Y N Y Y A phenotype variant of RLS
62 M / 6 An unpleasant “abnormal tickling” in his abdomen Y Y Y Y Y N Y N Y Y
62 F / 1 Electric currents, shocks, or sparks deep in her belly Y Y Y Y Y N Y N Y Y
2014 Japan 43 F / 0.17 Uncomfortable sensations including ‘twitching’ in his abdomen Y Y Y Y Y N Y N Y Y ‘Periodic abdominal movements’.
2015 Italy 81 M HBP, HLP, AAA, CAD, mild renal insufficiency and left renal artery stenosis. 34 Abdominal ‘cramps’ associated with unpleasant restless sensation of discomfort with the urge to move occurring in the evening when lying in relaxed wakefulness and when trying to fall asleep. Y Y Y Y Y N Y Y Y N A variant of periodic limb movement in wakefulness (LM/PLMW)
  1. M male, F female
  2. D1: the urge to move/unpleasant sensation, D2: at rest, D3: night, D4: activity, D5: Exclude other, such as drugs and peripheral neuropathy
  3. S1: Legs involved or not, S2: Insomnia, S3: family history, S4: Responsive to dopaminergic therapy, S5: PLMS in sleep, Y: yes, N: not
  4. HBP high blood pressure, HLP hyperlipidemia, AAA abdominal aortic aneurism, CAD coronary artery disease