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Table 1 Features of ever reported restless abdomen cases

From: Restless abdomen: a spectrum or a phenotype variant of restless legs syndrome?

 

Age & Gender

Medical history

Duration of symptoms, y

Main clinical manifestations

Diagnostic criteria

Supportive criteria

Nature of the disease

D1

D2

D3

D4

D5

S1

S2

S3

S4

S5

2003 Italy

72 M

Facial tics since adolescence

4

An unpleasant restless sensation originating in his lower abdomen, spreading then to the lower limbs and associated with a compelling need to move the legs.

Y

Y

Y

Y

Y

Y

Y

N

/

/

Part of the phenotypic spectrum of RLS

2011 Spain

62 M

/

14

Nocturnal awakenings due to a “nervous twitchy feeling” in his abdomen.

Y

Y

Y

Y

Y

N

Y

N

Y

Y

A phenotype variant of RLS

62 M

/

6

An unpleasant “abnormal tickling” in his abdomen

Y

Y

Y

Y

Y

N

Y

N

Y

Y

62 F

/

1

Electric currents, shocks, or sparks deep in her belly

Y

Y

Y

Y

Y

N

Y

N

Y

Y

2014 Japan

43 F

/

0.17

Uncomfortable sensations including ‘twitching’ in his abdomen

Y

Y

Y

Y

Y

N

Y

N

Y

Y

‘Periodic abdominal movements’.

2015 Italy

81 M

HBP, HLP, AAA, CAD, mild renal insufficiency and left renal artery stenosis.

34

Abdominal ‘cramps’ associated with unpleasant restless sensation of discomfort with the urge to move occurring in the evening when lying in relaxed wakefulness and when trying to fall asleep.

Y

Y

Y

Y

Y

N

Y

Y

Y

N

A variant of periodic limb movement in wakefulness (LM/PLMW)

  1. M male, F female
  2. D1: the urge to move/unpleasant sensation, D2: at rest, D3: night, D4: activity, D5: Exclude other, such as drugs and peripheral neuropathy
  3. S1: Legs involved or not, S2: Insomnia, S3: family history, S4: Responsive to dopaminergic therapy, S5: PLMS in sleep, Y: yes, N: not
  4. HBP high blood pressure, HLP hyperlipidemia, AAA abdominal aortic aneurism, CAD coronary artery disease