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Table 1 Comparison of clinical characteristics in patients with de novo DLB and PD

From: Comparisons of cardiovascular dysautonomia and cognitive impairment between de novo Parkinson’s disease and de novo dementia with Lewy bodies

Item

PD (N = 75)

DLB (N = 24)

p value a

Age (years)

72.2 ± 9.4

80.0 ± 5.0

0.001

Gender (male/female)

27/48

18/6

0.001

Symptom duration (years)

1.6 ± 1.6

1.9 ± 1.7

0.296

UPDRS motor score

20.3 ± 10.9

21.3 ± 10.8

0.236

Subtype (akinetic-rigid/tremor-dominant or mixed)

45/30

19/5

0.087

Olfaction

4.1 ± 2.8

2.4 ± 2.2

0.010

Mini-mental state examination

27.7 ± 2.2

20.0 ± 4.7

0.001

Frontal assessment battery

15.1 ± 2.8

10.2 ± 3.4

0.001

MIBG H/M ratio delay

1.44 ± 0.33

1.22 ± 0.39

0.001

BP fall in head-up tilt-table test (HUT) (mmHg)

23.6 ± 20.0

48.5 ± 23.6

0.001

Prevalence of OH (−/+)

36/39

1/23

0.001

Norepinephrine at rest in supine position in HUT (μg/ml)

217.9 ± 88.2

172.8 ± 82.5

0.009

Nocturnal fall in BP in ABPM (%)

8.5 ± 9.4

−4.4 ± 12.6

0.001

ABPM type (dipper/non dipper or riser type)

37/38

4/20

0.005

BP fall in postprandial hypotension (mmHg)

18.4 ± 13.1

32.8 ± 17.2

0.001

Postprandial hypotension (−/+)

42/33

6/18

0.008

BP in supine hypertension (mmHg)

134.8 ± 21.5

147.5 ± 19.2

0.011

Supine hypertension (−/+)

45/30

10/14

0.116

Neurogenic supine hypertension (−/+)

56/19

12/12

0.013

Constipation (−/+)

25/50

1/23

0.008

  1. a Wilcoxon rank sum test and Lepage analysis for continuous variables and χ2 test for binary variables
  2. UPDRS Unified Parkinson’s Disease Rating Scale, MIBG 123I-metaiodobenzylguanidine, H/M: ratio of the average pixel count in the heart (H) to that in the mediastinum (M), ABPM 24-h ambulatory blood pressure monitoring