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Table 4 Logistic regression models for prediction of early and late malignant progression with changes in MLS and ONSD/ETD ratio normalized by time interval

From: Optic nerve sheath diameter change in prediction of malignant cerebral edema in ischemic stroke: an observational study

Variables OR (95% CI) P-value Variables OR (95% CI) P-value
Early malignant progression
 Change from baseline in MLS, mm/hr. a 6.67 (1.51–29.53) 0.012 Change from baseline in ONSD/ETD, %/hr. a 1.64 (0.71–3.79) 0.249
 Age 1.08 (0.98–1.18) 0.114 Age 1.03 (0.97–1.09) 0.379
 Sex, male 0.77 (0.09–6.53) 0.814 Sex, male 0.77 (0.13–4.77) 0.783
 Initial DWI volume 1.02 (1.01–1.04) 0.006 Initial DWI volume 1.02 (1.01–1.03) 0.001
Late malignant progression
 Change from baseline in MLS, mm/day b 1.47 (1.08–2.01) 0.014 Change from baseline in ONSD/ETD, %/day b 1.38 (1.05–1.81) 0.021
 Age 0.93 (0.85–1.03) 0.178 Age 0.97 (0.9–1.04) 0.345
 Sex, male 0.24 (0.02–3.74) 0.308 Sex, male 0.78 (0.11–5.82) 0.811
 Initial DWI volume 1.02 (0.99–1.04) 0.136 Initial DWI volume 1.02 (1.00–1.04) 0.082
  1. aRate of change between CTbaseline and CTpostprocedure
  2. bRate of change between CTbaseline and CTD1
  3. MLS Midline shift, ONSD Optic nerve sheath diameter, ETD Eyeball transverse diameter, OR Odds ratio, DWI Diffusion weighted imaging