Fig. 1

MRI of Case 1 showing BCS-type lesion before and after treatment with cyclophosphamide. Tumefactive BCS-type lesion of the left corona radiata at symptom onset (A) with partial Gd + of the outermost layer (B arrow). A BCS-type lesion with residual ill-defined concentric morphology (C arrow) and no Gd + (D) 15 months from onset, after 6 pulses of cyclophosphamide. BCS-type lesion 5 years from onset (E arrow, F). a, c: FLAIR images. b, d: T1-weighted contrast-enhanced images. e: 3D FLAIR image. f: 3D T1-weighted contrast-enhanced image. BCS: Baló’s concentric sclerosis, Gd+: gadolinium enhancement