Fig. 2

MRI of Case 4. Tumefactive BCS-type lesion in the right centrum semiovale (A and B thick arrow) with incomplete central solid Gd + along with incomplete ring-like Gd + of the outer two layers (C thick arrow) and multiple typical non-enhancing MS lesions supratentorially (A thins arrows). BCS-type lesion with effacement of the “onion bulb” pattern (D and E thick arrow) 2 months after BCS onset and after corticosteroid treatment. BCS-type lesion (F thick arrow) at the 7th month of natalizumab treatment and 13th from the onset. a, d: FLAIR images. b, e: T2-weighted images. c: T1-weighted contrast-enhanced images. f: 3D FLAIR image. BCS: Baló’s concentric sclerosis, Gd+: gadolinium enhancement