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Table 1 Baseline characteristics of the primary cohort and the validation cohort

From: A new nomogram for individualized prediction of the probability of hemorrhagic transformation after intravenous thrombolysis for ischemic stroke patients

Baseline Primary cohort Validation cohort Test P value
(n = 131) (n = 63) statistic
Age 67(59–74) 70(62–78) − 1.441a 0.149
Sex, male 97(74.0) 39(61.9) 2.992 0.084
Admission SBP mmHg 152 ± 21 153 ± 21 −0.260b 0.796
Admission DBP mmHg 86(78–98) 85(78–92) −0.378a 0.705
Admission glucose 5.7(4.9--6.8) 6.1(5.2--7.6) −1.419a 0.156
Stroke 24(18.3) 6 (9.5) 2.518 0.113
Smoke 46(35.1) 19(30.2) 0.469 0.493
Dyslipidemia 20(15.3) 11(17.5) 0.152 0.696
Antiplatelets/anticoagulation 20(15.3) 9(14.3) 0.032 0.858
Hypertension 92(70.2) 40(63.5) 0.888 0.346
Diabetes 26(19.8) 18(28.6) 1.846 0.174
Atrial fibrillation 30 (22.9) 21(33.3) 2.389 0.122
CDS score    4.008 0.253
 0 31(23.7) 14(22.2)   
 1 60(45.8) 22(34.9)   
 2 32(24.4) 24(38.1)   
 3 8(6.1) 3(4.8)   
NIHSS score 6(3–11) 6(3–12) −0.219a 0.827
OTT for thrombolysis min 160(120–200) 183(130–210) −1.721a 0.085
Platelet *10^9 /L 181(152–215) 185(147–224) 0.198a 0.843
LDL mmol/L 2.58 ± 0.77 2.51 ± 0.62 0.626b 0.532
Creatinine umol/L 70.4(59.9–80.0) 69.9(55.4–84.0) −0.868a 0.385
CRP mg/L 3.7(1.7–13.3) 4.6(1.3–10.5) −0.582a 0.561
Uric acid mmol/L 300.2(241.0–351.3) 290.4(248.8–351.3) −0.164a 0.870
CSVD score    0.575 0.966
 0 23(17.6) 11(17.5)   
 1 46(35.1) 24(38.1)   
 2 39(29.8) 16(25.4)   
 3 18(13.7) 10(15.9)   
 4 5(3.8) 2(3.2)   
HT after thrombolysis 16(12.2) 6 (9.5) 0.306 0.580
  1. Abbreviations: SBP systolic blood pressure, DBP diastolic blood pressure, NIHSS National Institutes of Health Stroke Scale, OTT onset-to-treatment time, CDS chronic disease scale, LDL low-density lipoprotein, Hcy homocysteine, CRP C-reactive protein, CSVD cerebral small vessel disease, HT hemorrhagic transformation
  2. arepresents the Z value obtained by Mann-Whitney U test, bis t value by Student’s t-test, and the rest areλ2 value by Chi-square test