Is the sharp increasing trend of multiple sclerosis incidence real in Iran?

BMC Neurology

Table 1 Age standardized rate of multiple sclerosis Incidence in Iran during 2006–2016 (Per100000 Persons) in different age groups in both genders

Age groups	Years Genders	2006	2007	2008	2009	2010	2011	2012	2013	2014	2015	2016	APC^a	P-value
< 19	Males	0.21	0.33	0.41	0.47	0.53	0.55	0.66	0.61	0.50	0.55	0.44	7.7	0.01
	Females	1.06	1.28	1.32	1.82	1.98	2.54	2.49	2.42	2.36	1.96	1.71	5.2	0.01
	Total	0.63	0.75	0.78	1.01	1.09	1.53	1.56	1.51	1.43	1.26	1.02	6.0	0.01
20–29	Males	1.74	2.39	2.34	3.09	3.95	4.66	5.57	5.95	6.55	6.31	5.37	12.2	0.01
	Females	6.86	8.39	90.3	11.16	18.12	18.67	22.19	22.33	23.83	20.61	19.78	6.1	0.4
	Total	4.28	5.37	5.65	7.10	9.30	11.66	12.50	12.07	12.53	10.85	9.90	9.3	0.01
30–39	Males	1.79	3.14	2.68	3.14	4.05	5.62	5.85	5.51	6.66	6.49	5.93	12.0	0.01
	Females	6.83	11.20	11.78	14.66	19.54	21.22	21.25	20.79	21.77	21.56	20.85	11.3	0.01
	Total	4.26	6.75	6.61	8.06	10.68	13.31	15.11	15.47	17.17	17.16	16.58	13.9	0.01
40–49	Males	1.08	2.05	1.63	1.98	2.62	4.10	4.07	4.11	4.33	4.44	4.33	13.7	0.01
	Females	3.42	5.72	5.93	7.80	10.48	12.16	12.41	13.60	13.82	13.05	13.52	13.6	0.01
	Total	2.23	3.72	3.53	4.54	6.09	8.09	8.72	9.58	9.87	9.48	9.63	14.8	0.01
50–59	Males	0.39	0.41	0.21	0.73	0.62	1.16	1.45	1.20	1.79	1.74	2.03	22.5	0.01
	Females	0.86	1.65	1.39	2.29	3.36	3.02	2.40	3.43	3.62	3.97	4.63	14.9	0.01
	Total	0.62	0.94	0.67	1.33	1.66	2.09	2.07	2.55	3.00	3.16	3.67	19.7	0.01
> 60	Males	–	0.04	0.07	0.13	0.07	0.17	0.06	0.20	0.28	0.36	0.25	31.1	0.01
	Females	0.08	0.30	0.04	0.34	0.54	0.44	0.23	0.36	0.57	0.40	0.48	17.1	0.01
	Total	0.04	0.15	0.06	0.23	0.28	0.31	0.16	0.31	0.48	0.43	0.41	22.3	0.01

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