Table 1 Histological and immunohistological comparison among disease entities (based on Giannini et al. 2016 [1])
From: Malignant transformation of pleomorphic xanthoastrocytoma and differential diagnosis: case report
GBM (wild type) | PXA | APXA | Present case (1st resection) | Present case (2nd resection) | |
|---|---|---|---|---|---|
Mitosis (per 10 HPF) | + | < 5 | ≧5 | < 1 | 5 |
Necrosis | -~+ | Rare | -~+ | – | + |
MVP | -~+ | NA | uncommon | – | + |
Pleomorphism | -~+ | + | + | + | + |
IDH mutation | – | – | – | – | – |
ATRX mutation | – | NA | NA | – | – |
GFAP | + | + | + | + | + |
p53 | -~+ | Variable | NA | - (< 10%) | + (15%) |
MIB1 | 15–20% or more | <2~5% | NA | 1% | 21% |