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Table 1 Histological and immunohistological comparison among disease entities (based on Giannini et al. 2016 [1])

From: Malignant transformation of pleomorphic xanthoastrocytoma and differential diagnosis: case report

 GBM (wild type)PXAAPXAPresent case
(1st resection)
Present case
(2nd resection)
Mitosis (per 10 HPF)+< 55< 15
Necrosis-~+Rare-~++
MVP-~+NAuncommon+
Pleomorphism-~+++++
IDH mutation
ATRX mutationNANA
GFAP+++++
p53-~+VariableNA- (< 10%)+ (15%)
MIB115–20% or more<2~5%NA1%21%
  1. GBM glioblastoma, PXA pleomorphic xanthoastrocytoma, APXA anaplastic PXA, HPF high-power field, NA not available, MVP microvascular proliferation