Table 5 Relationships between CYP3A4 and CYP11A1 polymorphism and ischemic stroke risk according to the stratification by age
From: CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study
SNP ID | Allele/Genotype | > 61 | ≤61 | ||||||
|---|---|---|---|---|---|---|---|---|---|
Case | Control | OR (95%CI) | p | Case | Control | OR (95%CI) | p | ||
CYP3A4 rs3735451 | T | 403 | 287 | 1.00 | 0.063 | 302 | 399 | 1.00 | 0.217 |
C | 145 | 135 | 0.76 (0.58–1.01) | 104 | 165 | 0.83 (0.62–1.11) | |||
TT | 148 | 92 | 1.00 | 108 | 136 | 1.00 | |||
CT | 107 | 103 | 0.63 (0.41–0.96) | 0.031 | 86 | 127 | 0.85 (0.58–1.24) | 0.388 | |
CC | 19 | 16 | 0.77 (0.35–1.70) | 0.514 | 9 | 19 | 0.63 (0.27–1.47) | 0.290 | |
CT-CC | 126 | 119 | 0.65 (0.43–0.97) | 0.036 | 95 | 146 | 0.82 (0.57–1.18) | 0.288 | |
CYP3A4 rs4646440 | G | 439 | 314 | 1.00 | 0.051 | 329 | 440 | 1.00 | 0.334 |
A | 109 | 106 | 0.74 (0.54–1.00) | 77 | 122 | 0.84 (0.61–1.16) | |||
GG | 176 | 114 | 1.00 | 131 | 168 | 1.00 | |||
GA | 87 | 86 | 0.57 (0.37–0.88) | 0.012 | 67 | 104 | 0.82 (0.56–1.21) | 0.321 | |
AA | 11 | 10 | 0.86 (0.33–2.25) | 0.764 | 5 | 9 | 0.79 (0.26–2.44) | 0.684 | |
GA-AA | 98 | 96 | 0.60 (0.40–0.91) | 0.017 | 72 | 113 | 0.82 (0.56–1.20) | 0.302 | |
CYP3A4 rs4646437 | G | 486 | 368 | 1.00 | 0.487 | 360 | 485 | 1.00 | 0.284 |
A | 62 | 54 | 0.87 (0.59–1.28) | 46 | 77 | 0.80 (0.55–1.19) | |||
GG | 214 | 160 | 1.00 | 163 | 207 | 1.00 | |||
GA | 58 | 48 | 0.81 (0.49–1.32) | 0.396 | 34 | 71 | 0.59 (0.37–0.95) | 0.029 | |
AA | 2 | 3 | 0.48 (0.06–3.65) | 0.478 | 6 | 3 | 2.41 (0.57–10.25) | 0.233 | |
GA-AA | 60 | 51 | 0.79 (0.49–1.28) | 0.335 | 40 | 74 | 0.67 (0.43–1.04) | 0.073 | |
CYP11A1 rs12912592 | G | 498 | 376 | 1.00 | 0.659 | 364 | 527 | 1.00 | 0.043 |
T | 50 | 42 | 0.90 (0.58–1.38) | 42 | 37 | 1.64 (1.04–2.61) | |||
GG | 226 | 168 | 1.00 | 162 | 245 | 1.00 | |||
GT | 46 | 40 | 0.93 (0.55–1.58) | 0.798 | 40 | 37 | 1.84 (1.11–3.05) | 0.017 | |
TT | 2 | 1 | 0.53 (0.04–7.01) | 0.629 | 1 | 0 | / | / | |
GT-TT | 48 | 41 | 0.92 (0.55–1.54) | 0.744 | 41 | 37 | 1.89 (1.15–3.12) | 0.013 | |
CYP11A1 rs28681535 | G | 298 | 237 | 1.00 | 0.603 | 246 | 309 | 1.00 | 0.076 |
T | 250 | 185 | 1.08 (0.83–1.39) | 160 | 255 | 0.79 (0.61–1.02) | |||
GG | 75 | 67 | 1.00 | 80 | 87 | 1.00 | |||
GT | 148 | 103 | 1.31 (0.82–2.09) | 0.251 | 86 | 135 | 0.69 (0.46–1.05) | 0.081 | |
TT | 51 | 41 | 1.10 (0.61–1.99) | 0.743 | 37 | 60 | 0.60 (0.36–1.02) | 0.061 | |
GT-TT | 199 | 144 | 1.25 (0.81–1.95) | 0.318 | 123 | 195 | 0.66 (0.45–0.98) | 0.038 | |