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Table 5 Relationships between CYP3A4 and CYP11A1 polymorphism and ischemic stroke risk according to the stratification by age

From: CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study

SNP IDAllele/Genotype> 61≤61
CaseControlOR (95%CI)pCaseControlOR (95%CI)p
CYP3A4
rs3735451
T4032871.000.0633023991.000.217
C1451350.76 (0.58–1.01)1041650.83 (0.62–1.11)
TT148921.00 1081361.00 
CT1071030.63 (0.41–0.96)0.031861270.85 (0.58–1.24)0.388
CC19160.77 (0.35–1.70)0.5149190.63 (0.27–1.47)0.290
CT-CC1261190.65 (0.43–0.97)0.036951460.82 (0.57–1.18)0.288
CYP3A4
rs4646440
G4393141.000.0513294401.000.334
A1091060.74 (0.54–1.00)771220.84 (0.61–1.16)
GG1761141.00 1311681.00 
GA87860.57 (0.37–0.88)0.012671040.82 (0.56–1.21)0.321
AA11100.86 (0.33–2.25)0.764590.79 (0.26–2.44)0.684
GA-AA98960.60 (0.40–0.91)0.017721130.82 (0.56–1.20)0.302
CYP3A4
rs4646437
G4863681.000.4873604851.000.284
A62540.87 (0.59–1.28)46770.80 (0.55–1.19)
GG2141601.00 1632071.00 
GA58480.81 (0.49–1.32)0.39634710.59 (0.37–0.95)0.029
AA230.48 (0.06–3.65)0.478632.41 (0.57–10.25)0.233
GA-AA60510.79 (0.49–1.28)0.33540740.67 (0.43–1.04)0.073
CYP11A1
rs12912592
G4983761.000.6593645271.000.043
T50420.90 (0.58–1.38)42371.64 (1.04–2.61)
GG2261681.00 1622451.00 
GT46400.93 (0.55–1.58)0.79840371.84 (1.11–3.05)0.017
TT210.53 (0.04–7.01)0.62910//
GT-TT48410.92 (0.55–1.54)0.74441371.89 (1.15–3.12)0.013
CYP11A1
rs28681535
G2982371.000.6032463091.000.076
T2501851.08 (0.83–1.39)1602550.79 (0.61–1.02)
GG75671.00 80871.00 
GT1481031.31 (0.82–2.09)0.251861350.69 (0.46–1.05)0.081
TT51411.10 (0.61–1.99)0.74337600.60 (0.36–1.02)0.061
GT-TT1991441.25 (0.81–1.95)0.3181231950.66 (0.45–0.98)0.038
  1. SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval
  2. p values were calculated by logistic regression analysis with adjustments for age and gender
  3. p < 0.05 indicates statistical significance
  4. Bold indicates that the values have statistical significance