Rate of neuropathic progression in hereditary transthyretin amyloidosis with polyneuropathy and other peripheral neuropathies: a systematic review and meta-analysis

Table 3 Summarized Study Characteristics by Disease Type for NIS and NIS-LL Total Scores

Measure	Disease Type	N of Studies	Age^a: Mean (SD)	Male Gender: %	Initial Assessment Scores^a
Measure	Disease Type	N of Studies	Age^a: Mean (SD)	Male Gender: %	Mean	SD
NIS
	CMT	3	41 (18)	45%	60.10	19.80
	DPN	5	56 (8)	53%	13.46	8.70
	ATTRv-PN	4	61 (12)	71%	46.41	38.97
	IPN	1	66 (13)	58%	34.35	22.78
	Small fiber peripheral neuropathy	1	62 (11)	NA	NA	NA
NIS-LL
	CMT	1	51 (13)	50%	35.88	12.83
	DPN	5	54 (7)	45%	8.83	6.26
	ATTRv-PN	5	48 (11)	61%	15.45	14.56
	IPN	1	66 (13)	58%	24.25	14.06

^aMeans and SDs were calculated across studies for the particular measure and disease type, weighted by individual study sample sizes
Abbreviations: CMT Charcot-Marie-Tooth disease, DPN diabetic peripheral neuropathy, ATTRv-PN hereditary transthyretin amyloidosis with polyneuropathy, NA not available, NIS Neuropathy Impairment Score, NIS-LL Neuropathy Impairment Score – Lower Limbs, SD standard deviation

ISSN: 1471-2377