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Table 3 Summarized Study Characteristics by Disease Type for NIS and NIS-LL Total Scores

From: Rate of neuropathic progression in hereditary transthyretin amyloidosis with polyneuropathy and other peripheral neuropathies: a systematic review and meta-analysis

Measure Disease Type N of Studies Agea:
Mean (SD)
Male Gender:
%
Initial Assessment Scoresa
Mean SD
NIS
  CMT 3 41 (18) 45% 60.10 19.80
  DPN 5 56 (8) 53% 13.46 8.70
  ATTRv-PN 4 61 (12) 71% 46.41 38.97
  IPN 1 66 (13) 58% 34.35 22.78
  Small fiber peripheral neuropathy 1 62 (11) NA NA NA
NIS-LL
  CMT 1 51 (13) 50% 35.88 12.83
  DPN 5 54 (7) 45% 8.83 6.26
  ATTRv-PN 5 48 (11) 61% 15.45 14.56
  IPN 1 66 (13) 58% 24.25 14.06
  1. aMeans and SDs were calculated across studies for the particular measure and disease type, weighted by individual study sample sizes
  2. Abbreviations: CMT Charcot-Marie-Tooth disease, DPN diabetic peripheral neuropathy, ATTRv-PN hereditary transthyretin amyloidosis with polyneuropathy, NA not available, NIS Neuropathy Impairment Score, NIS-LL Neuropathy Impairment Score – Lower Limbs, SD standard deviation