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Table 4 Difference in Estimates of Mean Annual Rate of Change Measured by NIS and NIS-LL between Studies of Patients with ATTRv-PN and Studies of Patients with Other Peripheral Neuropathies

From: Rate of neuropathic progression in hereditary transthyretin amyloidosis with polyneuropathy and other peripheral neuropathies: a systematic review and meta-analysis

Measure ATTRv-PN vs. Other peripheral neuropathiesa ATTRv-PN vs. Other peripheral neuropathies,
adjusting for initial assessment scoreb
Estimated Difference in Mean Annual Rate of Change 95% CI P Estimated Difference in Mean Annual Rate of Change 95% CI P
NIS 12.45 9.34, 15.57 < 0.001 11.97 7.77, 16.18 < 0.001
NIS-LL 6.96 4.57, 9.35 < 0.001 6.47 4.01, 8.92 < 0.001
  1. aThe estimated difference, 95% CI, and P value were based on the meta-regression model with the mean annual rate of change in NIS or NIS-LL total score as the dependent variable and the dichotomous variable for disease type (ATTRv-PN vs. other peripheral neuropathies) as the independent variable
  2. bThe estimated difference, 95% CI, and P value were based on the meta-regression model with the mean annual rate of change in NIS or NIS-LL total score as the dependent variable, and the initial assessment score and the dichotomous variable for disease type (ATTRv-PN vs. other peripheral neuropathies) as independent variables
  3. Abbreviations: CI confidence interval, ATTRv-PN hereditary transthyretin amyloidosis with polyneuropathy, NIS Neuropathy Impairment Score, NIS-LL Neuropathy Impairment Score – Lower Limbs