Rate of neuropathic progression in hereditary transthyretin amyloidosis with polyneuropathy and other peripheral neuropathies: a systematic review and meta-analysis

Table 4 Difference in Estimates of Mean Annual Rate of Change Measured by NIS and NIS-LL between Studies of Patients with ATTRv-PN and Studies of Patients with Other Peripheral Neuropathies

Measure	ATTRv-PN vs. Other peripheral neuropathies^a			ATTRv-PN vs. Other peripheral neuropathies, adjusting for initial assessment score^b
Measure	Estimated Difference in Mean Annual Rate of Change	95% CI	P	Estimated Difference in Mean Annual Rate of Change	95% CI	P
NIS	12.45	9.34, 15.57	< 0.001	11.97	7.77, 16.18	< 0.001
NIS-LL	6.96	4.57, 9.35	< 0.001	6.47	4.01, 8.92	< 0.001

^aThe estimated difference, 95% CI, and P value were based on the meta-regression model with the mean annual rate of change in NIS or NIS-LL total score as the dependent variable and the dichotomous variable for disease type (ATTRv-PN vs. other peripheral neuropathies) as the independent variable
^bThe estimated difference, 95% CI, and P value were based on the meta-regression model with the mean annual rate of change in NIS or NIS-LL total score as the dependent variable, and the initial assessment score and the dichotomous variable for disease type (ATTRv-PN vs. other peripheral neuropathies) as independent variables
Abbreviations: CI confidence interval, ATTRv-PN hereditary transthyretin amyloidosis with polyneuropathy, NIS Neuropathy Impairment Score, NIS-LL Neuropathy Impairment Score – Lower Limbs

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