Table 2 Characteristics of studies comparing IVT with non-IVT in AF pattents
Study | Study design | Comparison | No. of patients | age, y | Men (%) | Treatment | Hypertension (%) | Diabetes mellitus (%) | Dyslipidemia (%) | Baseline NIHSS | Onset to needle (min) | Mortality, % | SICH, % |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bluhmki 2009 [5] | prospective RCT | IVT/Non-IVT | 53/55 | NR | NR | rtPA 3–4.5 h | NR | NR | NR | NR | NR | 22.6/14.5, 90d | 17.0/6.6 |
Zhang 2010 [7] | retrospective | IVT/Non-IVT | 22/44 | 68.3/70.4 | 40.9/43.2 | rtPA < 4.5 h | 72.7/63.6 | 13.6/20.5 | NR | 12.0/12.6 | 203.7/NR | 18.2/20.5, 90d | 18.2/6.8 |
Frank 2012 [9] | retrospective | IVT/Non-IVT | 639/992 | 74.2/73.9 | 47.3/47.6 | rtPA < 3 h | 71.1/75.5 | NR | NR | 15 /14 | NR | 21.8/23.2, 90d | 2.7/0.9 |
Saposnik 2013 [11] | prospective | IVT/Non-IVT | 316/1373 | NR | NR | rtPA | NR | NR | NR | NR | NR | 26.3/18.1, 30d | NR |
Padjen 2014 [20] | prospective | IVT/Non-IVT | 34/97 | 68/72 | 58.8/51.5 | rtPA < 4.5 h | 94.1/87.6 | 20.6/24.7 | 29.4/38.8 | 11/14 | NR | 14.7/45.4, 90d | 5.9/4.1 |
Zhao 2016 [21] | retrospective | IVT/Non-IVT | 151/116 | 71.3/73.5 | 43.7/43.1 | rtPA < 4.5 h | 73.5/67.2 | 15.9/19.0 | 17.2/12.1 | 15.1/13.9 | 165.7/179.3 | 23.2/25.0, 90d | 13.9/1.7 |
Yang 2019 [15] | retrospective | IVT/Non-IVT | 47/31 | 71.2/74.7 | 34.0/58.1 | rtPA 3-9 h | 74.5/93.4 | 19.1/32.2 | NR | 11.5 /13.7 | 322.9 /310.4 | 10.6/14.8, 90d | 2.1/0 |