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Table 2 Characteristics of studies comparing IVT with non-IVT in AF pattents

From: Efficacy and safety of thrombolysis for acute ischemic stroke with atrial fibrillation: a meta-analysis

Study Study design Comparison No. of patients age, y Men (%) Treatment Hypertension (%) Diabetes mellitus (%) Dyslipidemia (%) Baseline NIHSS Onset to needle (min) Mortality, % SICH, %
Bluhmki 2009 [5] prospective RCT IVT/Non-IVT 53/55 NR NR rtPA
3–4.5 h
NR NR NR NR NR 22.6/14.5, 90d 17.0/6.6
Zhang 2010 [7] retrospective IVT/Non-IVT 22/44 68.3/70.4 40.9/43.2 rtPA
< 4.5 h
72.7/63.6 13.6/20.5 NR 12.0/12.6 203.7/NR 18.2/20.5, 90d 18.2/6.8
Frank 2012 [9] retrospective IVT/Non-IVT 639/992 74.2/73.9 47.3/47.6 rtPA
< 3 h
71.1/75.5 NR NR 15 /14 NR 21.8/23.2, 90d 2.7/0.9
Saposnik 2013 [11] prospective IVT/Non-IVT 316/1373 NR NR rtPA NR NR NR NR NR 26.3/18.1, 30d NR
Padjen 2014 [20] prospective IVT/Non-IVT 34/97 68/72 58.8/51.5 rtPA
< 4.5 h
94.1/87.6 20.6/24.7 29.4/38.8 11/14 NR 14.7/45.4, 90d 5.9/4.1
Zhao 2016 [21] retrospective IVT/Non-IVT 151/116 71.3/73.5 43.7/43.1 rtPA
< 4.5 h
73.5/67.2 15.9/19.0 17.2/12.1 15.1/13.9 165.7/179.3 23.2/25.0, 90d 13.9/1.7
Yang 2019 [15] retrospective IVT/Non-IVT 47/31 71.2/74.7 34.0/58.1 rtPA
3-9 h
74.5/93.4 19.1/32.2 NR 11.5 /13.7 322.9 /310.4 10.6/14.8, 90d 2.1/0