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Table 3 Subgroup analyses of efficacy and safety of thrombolysis for acute IS with AF based on study design

From: Efficacy and safety of thrombolysis for acute ischemic stroke with atrial fibrillation: a meta-analysis

Study design mRS 0–1 Test of association Heterogeneity
AF Non-AF OR (95% CI) P I2 (%) P
Retrospective(n = 6) 250/886 990/2777 0.68 (0.57–0.81) < 0.001 75.0 0.006
Prospective(n = 4) 101/568 782/2358 0.41 (0.32–0.52) < 0.001 0.0 0.343
  IVT Non-IVT OR (95% CI) P I2 (%) P
Retrospective(n = 4) 238/859 272/1183 1.24 (1.01–1.52) 0.039 74.5 0.008
Prospective(n = 3) 65/403 409/2004 0.65 (0.48–0.87) 0.005 92.1 < 0.001
  mRS 0–2 Test of association Heterogeneity
AF Non-AF OR (95% CI) P I2 (%) P
Retrospective(n = 8) 363/976 1523/2962 0.53 (0.46–0.62) < 0.001 63.2 0.008
Prospective(n = 3) 138/515 848/1993 0.44 (0.35–0.55) < 0.001 0 0.474
  IVT Non-IVT OR (95% CI) P I2 (%) P
Retrospective(n = 4) 302/859 382/1183 1.10 (0.91–1.33) 0.317 50.6 0.108
Prospective(n = 2) 73/350 636/1949 0.53 (0.40–0.70) < 0.001 96.7 < 0.001
  Mortality Test of association Heterogeneity
AF Non-AF OR (95% CI) P I2 (%) P
Retrospective(n = 8) 204/1044 378/3047 1.86 (1.54–2.25) < 0.001 49.7 0.053
Prospective(n = 6) 189/983 329/3089 2.30 (1.88–2.82) < 0.001 25.7 0.242
  IVT Non-IVT OR (95% CI) P I2 (%) P
Retrospective(n = 4) 183/859 272/1183 0.91 (0.74–1.13) 0.413 0.0 0.998
Prospective(n = 3) 100/403 387/2004 1.34 (1.04–1.73) 0.025 86.3 0.001
  sICH Test of association Heterogeneity
AF Non-AF OR (95% CI) P I2 (%) P
Retrospective(n = 8) 48/1026 71/3022 1.67 (1.14–2.46) 0.009 0 0.490
Prospective(n = 5) 78/939 178/3048 1.56 (1.17–2.07) 0.002 0 0.509
  IVT Non-IVT OR (95% CI) P I2 (%) P
Retrospective(n = 4) 43/857 14/1183 4.04 (2.16–7.55) < 0.001 0.0 0.566
Prospective(n = 2) 11/87 8/152 2.18 (0.80–5.88) 0.126 0.0 0.592