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Table 1 Univariate analysis for clinical profiles of CSVD burdenlow and CSVD burdenhigh groups

From: Left ventricular ejection fraction and right atrial diameter are associated with deep regional CBF in arteriosclerotic cerebral small vessel disease

  CSVD burdenlow
n = 61
CSVD burdenhigh
n = 42
P
Demographics
 Age, y 61.53 ± 10.71 65.97 ± 13.23 0.063
 Male, n (%) 35 (57.4%) 29 (69.0%) 0.230
 Smoking, n (%) 19 (31.1%) 10 (23.8%) 0.416
 Alcohol Drinking, n (%) 5 (8.2%) 0 (0.0%) 0.151
 BMI 23.04 ± 3.40 24.46 ± 3.23 0.054
Medical History, n (%)
 Hypertension 33 (54.1%) 38 (90.5%) < 0 .001
 Impaired Fasting Glucose 1 (1.6%) 1 (2.4%) 1.000
 Impaired Glucose Tolerance 4 (6.6%) 3 (7.1%) 1.000
 Diabetes Mellitus 10 (16.4%) 16 (38.1%) 0.013
 Hyperlipidemia 37 (60.7%) 25 (59.5%) 0.908
 Atrial Fibrillation 1 (1.6%) 1 (2.4%) 1.000
 Previous myocardial infarction 2 (3.3%) 4 (9.5%) 0.184
 Symptomatic Stroke 27 (44.3%) 28 (66.7%) 0.025
Medication History, n (%)
 Antiplatelet therapy 7 (11.5%) 5 (11.9%) 1.000
 Statins 5 (8.2%) 6 (14.3%) 0.510
 Antihypertensive Drugs 18 (29.5%) 25 (59.5%) 0.002
 Antidiabetic Drugs 8 (13.1%) 11 (26.2%) 0.930
Metabolic Variablesa
 Fasting Glucose (mmol/L) 5.08 (1.16) 5.41 (1.03) 0.024
 HbA1c (%) 5.60 (0.67) 5.85 (0.80) 0.493
 Total Cholesterol (mmol/L) 4.82 ± 1.17 4.48 ± 1.37 0.434
 Triglyceride (mmol/L) 1.32 (0.67) 1.28 (0.93) 0.511
 HDL-C (mmol/L) 1.20 ± 0.32 1.13 ± 0.33 0.365
 LDL-C (mmol/L) 3.03 ± 0.92 2.71 ± 1.04 0.400
 ApoA1 (g/L) 1.32 ± 0.26 1.30 ± 0.26 0.887
 ApoB 100 (g/L) 0.98 (0.42) 0.89 (0.53) 0.430
 Lp(a) (mg/L) 146.50 (273.00) 137.50 (181.75) 0.957
 Homocysteine (μmol/L) 13.21 (6.63) 14.44 (8.40) 0.653
 Vitamin B1 (nmol/L) 67.28 (38.04) 68.69 (27.82) 0.407
 Vitamin B6(μmol/L) 19.45 (8.02) 19.26 (7.57) 0.957
 Vitamin B12(pg/mL) 248.27 (70.93) 239.08 (77.11) 0.330
 25-(OH) Vitamin D (nmol/L) 66.90 ± 19.42 62.11 ± 18.15 0.154
 eGFR (ml/min/1.73m2) 90.45 (19.18) 77.79 (34.07) 0.039
Intima Media Thickness (mm) 0.870 ± 0.166 0.875 ± 0.170 0.896
Echocardiographic Parameters
 LAD (mm) 30.76 ± 3.45 32.40 ± 3.38 0.036
 LVEDV (ml) 90.58 ± 19.24 96.16 ± 17.03 0.179
 RVD (mm) 20.07 ± 3.49 21.06 ± 2.81 0.172
 RAD (mm) 41.26 ± 4.94 41.86 ± 4.31 0.571
 LVFS (%) 37.89 ± 3.47 37.46 ± 4.53 0.626
 E/A Ratio 0.86 ± 0.30 0.76 ± 0.22 0.080
 LVEF (%) 67.91 ± 4.69 67.26 ± 5.49 0.654
  1. aResults were presented as mean ± SD for normally distributed continuous variables or median (interquartile range, IQR) for skewedly distributed continuous variables
  2. Abbreviations: BMI body mass index, HbA1c glycated haemoglobin A1c, LDL-C low density lipoprotein-cholesterol, HDL-C high density lipoprotein-cholesterol, ApoA1 apolipoprotein A1, ApoB100 apolipoprotein B100, Lp(a) lipoprotein (a), eGFR estimated glomerular filtration rate, LAD left atrial diameter, LVEDV left ventricular end-diastolic volume, RVD right ventricular diameter, RAD right atrial diameter, LVFS left ventricular fraction shortening, E/A ratio [transmitral early-diastolic peak velocity wave (E wave)]/ [transmitral atrial wave velocity (A wave)] ratio, LVEF left ventricular ejection fraction