Table 1 Univariate analysis for clinical profiles of CSVD burdenlow and CSVD burdenhigh groups
CSVD burdenlow n = 61 | CSVD burdenhigh n = 42 | P | |
|---|---|---|---|
Demographics | |||
Age, y | 61.53 ± 10.71 | 65.97 ± 13.23 | 0.063 |
Male, n (%) | 35 (57.4%) | 29 (69.0%) | 0.230 |
Smoking, n (%) | 19 (31.1%) | 10 (23.8%) | 0.416 |
Alcohol Drinking, n (%) | 5 (8.2%) | 0 (0.0%) | 0.151 |
BMI | 23.04 ± 3.40 | 24.46 ± 3.23 | 0.054 |
Medical History, n (%) | |||
Hypertension | 33 (54.1%) | 38 (90.5%) | < 0 .001 |
Impaired Fasting Glucose | 1 (1.6%) | 1 (2.4%) | 1.000 |
Impaired Glucose Tolerance | 4 (6.6%) | 3 (7.1%) | 1.000 |
Diabetes Mellitus | 10 (16.4%) | 16 (38.1%) | 0.013 |
Hyperlipidemia | 37 (60.7%) | 25 (59.5%) | 0.908 |
Atrial Fibrillation | 1 (1.6%) | 1 (2.4%) | 1.000 |
Previous myocardial infarction | 2 (3.3%) | 4 (9.5%) | 0.184 |
Symptomatic Stroke | 27 (44.3%) | 28 (66.7%) | 0.025 |
Medication History, n (%) | |||
Antiplatelet therapy | 7 (11.5%) | 5 (11.9%) | 1.000 |
Statins | 5 (8.2%) | 6 (14.3%) | 0.510 |
Antihypertensive Drugs | 18 (29.5%) | 25 (59.5%) | 0.002 |
Antidiabetic Drugs | 8 (13.1%) | 11 (26.2%) | 0.930 |
Metabolic Variablesa | |||
Fasting Glucose (mmol/L) | 5.08 (1.16) | 5.41 (1.03) | 0.024 |
HbA1c (%) | 5.60 (0.67) | 5.85 (0.80) | 0.493 |
Total Cholesterol (mmol/L) | 4.82 ± 1.17 | 4.48 ± 1.37 | 0.434 |
Triglyceride (mmol/L) | 1.32 (0.67) | 1.28 (0.93) | 0.511 |
HDL-C (mmol/L) | 1.20 ± 0.32 | 1.13 ± 0.33 | 0.365 |
LDL-C (mmol/L) | 3.03 ± 0.92 | 2.71 ± 1.04 | 0.400 |
ApoA1 (g/L) | 1.32 ± 0.26 | 1.30 ± 0.26 | 0.887 |
ApoB 100 (g/L) | 0.98 (0.42) | 0.89 (0.53) | 0.430 |
Lp(a) (mg/L) | 146.50 (273.00) | 137.50 (181.75) | 0.957 |
Homocysteine (μmol/L) | 13.21 (6.63) | 14.44 (8.40) | 0.653 |
Vitamin B1 (nmol/L) | 67.28 (38.04) | 68.69 (27.82) | 0.407 |
Vitamin B6(μmol/L) | 19.45 (8.02) | 19.26 (7.57) | 0.957 |
Vitamin B12(pg/mL) | 248.27 (70.93) | 239.08 (77.11) | 0.330 |
25-(OH) Vitamin D (nmol/L) | 66.90 ± 19.42 | 62.11 ± 18.15 | 0.154 |
eGFR (ml/min/1.73m2) | 90.45 (19.18) | 77.79 (34.07) | 0.039 |
Intima Media Thickness (mm) | 0.870 ± 0.166 | 0.875 ± 0.170 | 0.896 |
Echocardiographic Parameters | |||
LAD (mm) | 30.76 ± 3.45 | 32.40 ± 3.38 | 0.036 |
LVEDV (ml) | 90.58 ± 19.24 | 96.16 ± 17.03 | 0.179 |
RVD (mm) | 20.07 ± 3.49 | 21.06 ± 2.81 | 0.172 |
RAD (mm) | 41.26 ± 4.94 | 41.86 ± 4.31 | 0.571 |
LVFS (%) | 37.89 ± 3.47 | 37.46 ± 4.53 | 0.626 |
E/A Ratio | 0.86 ± 0.30 | 0.76 ± 0.22 | 0.080 |
LVEF (%) | 67.91 ± 4.69 | 67.26 ± 5.49 | 0.654 |