Clinical impact of estradiol/testosterone ratio in patients with acute ischemic stroke

BMC Neurology

Table 4 Univariate and multivariate analyses for early unfavorable outcomes

	Univariate analysis			Multivariate analysis
	OR	95% CI	P-value	OR	95% CI	P-value
Age	1.087	1.047-1.128	<0.001	1.061	1.006-1.119	0.029
Systolic blood pressure	0.994	0.981-1.008	0.405
Diastolic blood pressure	1.001	0.984-1.018	0.886
Body mass index	1.018	0.909-1.141	0.752
Hypertension	1.985	1.024-3.848	0.042	2.601	0.849-7.963	0.094
Diabetes mellitus	1.981	0.941-4.170	0.072
Smoking, current	1.076	0.535-2.166	0.837
Alcohol, current	1.328	0.681-2.587	0.405
Cardiovascular disease^a	1.646	0.747-3.627	0.217
Hyperlipidemia	1.889	0.970-3.677	0.061
Atrial fibrillation	2.556	1.054-6.194	0.038	1.657	0.435-6.319	0.460
CKD	1.773	0.809-3.883	0.153
Total cholesterol	1.001	0.994-1.009	0.750
Triglyceride	0.998	0.994-1.001	0.221
HDL-cholesterol	0.975	0.944-1.008	0.134
LDL-cholesterol	1.003	0.995-1.011	0.481
HbA1c	1.034	0.848-1.261	0.742
eGFR	0.984	0.963-1.006	0.148
Admission NIHSS score	1.682	1.395-2.029	<0.001	1.539	1.267-1.871	<0.001
Stroke subtypes
Large artery atherosclerosis	Reference
Cardioembolism	2.177	0.905-5.233	0.082	2.112	0.571-7.813	0.263
Small vessel disease	0.260	0.087-0.773	0.015	0.206	0.034-1.237	0.084
Unknown/undetermined causes	0.390	0.145-1.047	0.062	0.590	0.143-2.427	0.464
E2 (estradiol)	1.011	1.004-1.018	0.002	1.003	0.993-1.014	0.507
Total testosterone	0.961	0.919-1.005	0.080
Free testosterone	0.169	0.012-2.450	0.192
Progesterone	1.616	0.988-2.642	0.056
17-OH progesterone	0.979	0.820-1.170	0.815
E/T ratio	1.134	1.052-1.221	0.001	1.167	1.053-1.294	0.003

OR odds ratio, CI confidence interval, CKD chronic kidney disease, HDL high-density lipoprotein, LDL low-density lipoprotein, eGFR estimated glomerular filtration rate, NIHSS National Institutes of Health Stroke Scale, E/T ratio estradiol-to-testosterone ratio
^aCardiovascular disease includes coronary heart disease, heart failure, or peripheral arterial disease

ISSN: 1471-2377