Increase of blood-brain barrier leakage is related to cognitive decline in vascular mild cognitive impairment

BMC Neurology

Table 3 Leakage rate, area under the leakage curve, and fractional blood plasma volume in patients with vascular mild cognitive impairment (vMCI) and controls

	vMCI group	Control	Univariable ^a		Multivariable ^b
	vMCI group	Control	β P		β P
NAWM
K_trans (10^− 4 min^− 1)	0.31 ± 0.14	0.20 ± 0.17	− 0.109	0.016	− 0.109	0.016
AUC	4.41 ± 1.04	3.52 ± 1.20	−0.886	0.008	− 0.888	0.006
Vp (10^–2)	4.76 ± 1.97	7.51 ± 2.33	2.751	<0.001	2.751	<0.001
WMH
K_trans (10⁻⁴ min⁻¹)	0.56 ± 0.24	0.29 ± 0.18	−0.275	<0.001	−0.275	<0.001
AUC	6.02 ± 1.77	4.13 ± 1.25	−1.896	<0.001	−1.896	<0.001
Vp (10⁻²)	8.43 ± 4.39	10.49 ± 5.04	2.058	0.129	0.218	0.115
CGM
K_trans (10⁻⁴ min⁻¹)	1.57 ± 0.70	0.93 ± 0.56	−0.642	0.001	−0.642	0.001
AUC	17.90 ± 4.37	16.10 ± 5.76	−1.798	0.217	0.453	0.800
Vp (10⁻²)	20.92 ± 7.97	30.12 ± 9.73	9.192	0.001	9.170	<0.001
DGM
K_trans (10⁻⁴ min⁻¹)	0.99 ± 0.50	0.54 ± 0.35	−0.442	0.001	−0.442	0.001
AUC	11.44 ± 2.11	10.24 ± 3.43	−1.200	0.123	0.122	0.429
Vp (10⁻²)	15.36 ± 5.51	19.79 ± 7.10	4.434	0.017	4.445	0.009

Data are presented as mean ± SD
Abbreviations: NAWM normal-appearing white matter, WMH white matter hyperintensities, CGM cortex grey matter, DGM deep grey matter, K_trans leakage rate, AUC area under the leakage curve, V_p fractional blood plasma volume

ISSN: 1471-2377