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Table 3 Leakage rate, area under the leakage curve, and fractional blood plasma volume in patients with vascular mild cognitive impairment (vMCI) and controls

From: Increase of blood-brain barrier leakage is related to cognitive decline in vascular mild cognitive impairment

  vMCI group Control Univariable a Multivariable b
β P β P
NAWM
 Ktrans (10− 4 min− 1) 0.31 ± 0.14 0.20 ± 0.17 − 0.109 0.016 − 0.109 0.016
 AUC 4.41 ± 1.04 3.52 ± 1.20 −0.886 0.008 − 0.888 0.006
 Vp (10–2) 4.76 ± 1.97 7.51 ± 2.33 2.751 <0.001 2.751 <0.001
WMH
 Ktrans (10−4 min−1) 0.56 ± 0.24 0.29 ± 0.18 −0.275 <0.001 −0.275 <0.001
 AUC 6.02 ± 1.77 4.13 ± 1.25 −1.896 <0.001 −1.896 <0.001
 Vp (10−2) 8.43 ± 4.39 10.49 ± 5.04 2.058 0.129 0.218 0.115
CGM
 Ktrans (10−4 min−1) 1.57 ± 0.70 0.93 ± 0.56 −0.642 0.001 −0.642 0.001
 AUC 17.90 ± 4.37 16.10 ± 5.76 −1.798 0.217 0.453 0.800
 Vp (10−2) 20.92 ± 7.97 30.12 ± 9.73 9.192 0.001 9.170 <0.001
DGM
 Ktrans (10−4 min−1) 0.99 ± 0.50 0.54 ± 0.35 −0.442 0.001 −0.442 0.001
 AUC 11.44 ± 2.11 10.24 ± 3.43 −1.200 0.123 0.122 0.429
 Vp (10−2) 15.36 ± 5.51 19.79 ± 7.10 4.434 0.017 4.445 0.009
  1. Data are presented as mean ± SD
  2. Abbreviations: NAWM normal-appearing white matter, WMH white matter hyperintensities, CGM cortex grey matter, DGM deep grey matter, Ktrans leakage rate, AUC area under the leakage curve, Vp fractional blood plasma volume